Evidence map›Paper›PMID 29676995›Full record

ArticleAging2018

Physical decline and survival in the elderly are affected by the genetic variability of amino acid transporter genes.

Paolina Crocco, Eneida Hoxha, Serena Dato, Francesco De Rango, Alberto Montesanto, Giuseppina Rose, Giuseppe Passarino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paolina Crocco *Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Eneida Hoxha *Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Serena DatoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Francesco De RangoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Alberto MontesantoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Giuseppina Rose *Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Giuseppe Passarino *Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
University of Calabria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amino acid (AA) availability is a rate-limiting factor in the regulation of muscle protein metabolism and, consequently, a risk factor for age-related decline in muscle performance. AA transporters are emerging as sensors of AA availability and activators of mTORC1 signalling, acting as transceptors. Here, we evaluated the association of 58 single nucleotide polymorphisms (SNPs) in 10 selected AA transporter genes with parameters of physical performance (Hand Grip, Activity of Daily Living, Walking time). By analysing a sample of 475 subjects aged 50-89 years, we found significant associations with

Indexed as

Activities of Daily LivingAgedAged, 80 and overAmino Acid Transport SystemsCross-Sectional StudiesFemaleGenotypeHand StrengthHumansLongevityLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotideSurvival AnalysisAmino Acid Transport SystemsADLagingamino acid transporter genesHand gripmTORC1muscle declinesarcopenia

Identifiers

PMID29676995
PMCPMC5940118
OpenAlexW2802202570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.