Trial reportBrain, behavior, and immunity2018
Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection.
Trial report in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short-term Effects of Methamphetamine Exposure on Residual Viral Transcription During Treated HIV Disease
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- A positive affect intervention alters leukocyte DNA methylation in sexual minority men with HIV who use methamphetamine.Brain, behavior, and immunity · 2024Trial
- Blue Monday: Co-occurring Stimulant Use and HIV Persistence Predict Dysregulated Catecholamine Synthesis.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- Integrating evidence-based methamphetamine interventions into methadone clinics: Structural barriers and implementation opportunities.The International journal on drug policy · 2026Article
- Body talk: Correlates of gut-immune dysregulation phenotypes in people living with HIV who use methamphetamine.Brain, behavior, & immunity - health · 2026Article
- Article
- Cannabis Use and Biomarkers of Inflammation, Immune Activation, and Microbial Translocation in Persons with HIV.Cannabis and cannabinoid research · 2024Article
- Gender and Intersecting Barriers and Facilitators to Access the HIV Cascade of Care in Manitoba, Canada, Before and During the COVID-19 Pandemic: A Qualitative Study.Tropical medicine and infectious disease · 2024Article
- Social Genomics of Methamphetamine Use, HIV Viral Load, and Social Adversity.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022Article
- Discrimination is associated with C-reactive protein among young sexual minority men.Journal of behavioral medicine · 2022Article
- HIV-related drivers of sexual compulsivity and sexuality in sexual minority men who use methamphetamine.Journal of neurovirology · 2022Article
- Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana.Retrovirology · 2022Article
- Article
- "It's how we get to know each other": Substance use, connectedness, and sexual activity among men who have sex with men who are living with HIV.BMC public health · 2022Article
- Review
- Comparative impact of methamphetamine and other drug use on viral suppression among sexual minority men on antiretroviral therapy.Drug and alcohol dependence · 2021Article
- Trends in Methamphetamine Use Among Men Who Have Sex with Men in New York City, 2004-2017.AIDS and behavior · 2021Article
- Intersecting minority statuses and tryptophan degradation among stimulant-using, sexual minority men living with HIV.Journal of consulting and clinical psychology · 2021Article
- Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine.Journal of neurovirology · 2021Article
- Lifetime Methamphetamine Use Disorder and Reported Sleep Quality in Adults Living with HIV.AIDS and behavior · 2020Article
- Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.Journal of neurovirology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Stimulant use may accelerate HIV disease progression through biological and behavioral pathways. However, scant research with treated HIV-positive persons has examined stimulant-associated alterations in pathophysiologic processes relevant to HIV pathogenesis. In a sample of 55 HIV-positive, methamphetamine-using sexual minority men with a viral load less than 200 copies/mL, we conducted RNA sequencing to examine patterns of leukocyte gene expression in participants who had a urine sample that was reactive for stimulants (n = 27) as compared to those who tested non-reactive (n = 28). Results indicated differential expression of 32 genes and perturbation of 168 pathways in recent stimulant users. We observed statistically significant differential expression of single genes previously associated with HIV latency, cell cycle regulation, and immune activation in recent stimulant users (false discovery rate p < 0.10). Pathway analyses indicated enrichment for genes associated with inflammation, innate immune activation, neuroendocrine hormone regulation, and neurotransmitter synthesis. Recent stimulant users displayed concurrent elevations in plasma levels of tumor necrosis factor - alpha (TNF-α) but not interleukin 6 (IL-6). Further research is needed to examine the bio-behavioral mechanisms whereby stimulant use may contribute to HIV persistence and disease progression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.