Evidence map›Paper›PMID 29680203›Full record

SynthesisJournal of the American Medical Directors Association2018

Cognitive-Based Interventions to Improve Mobility: A Systematic Review and Meta-analysis.

Uros Marusic, Joe Verghese, Jeannette R Mahoney

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Medical Directors Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 4 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03860441 nacompletednot on this map

Holistic Approach for Active and Healthy Aging: Physical and Cognitive Activity, and Nutrition

TypeinterventionalSponsorScience and Research Centre KoperRan2017 to 2018Enrolled77ConditionsCognitive Decline, Cognitive Impairment, Aging, Motor Coordination or FunctionArmsComputerized cognitive training
NCT06598163 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of a Digital Health App Five Lives MED to Improve Cognitive Function in Patients With Mild Cognitive Impairment: a Randomised Controlled Trial

TypeinterventionalSponsorSharpTxRan2025 to 2026Enrolled170ConditionsMild Cognitive ImpairmentArmsFive Lives MED
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  3. Falls in older adults: a practical approach.Arquivos de neuro-psiquiatria · 2022
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  7. Does Cognitive Training Reduce Falls across Ten Years?: Data from the ACTIVE Trial.International journal of environmental research and public health · 2023
    Trial
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Uros MarusicInstitute for Kinesiology Research, Science and Research Centre Koper, Koper, Slovenia; Department of Health Sciences, Alma Mater Europaea-ECM, Maribor, Slovenia. Electronic address: umarusic@outlook.com.
Joe VergheseDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Jeannette R MahoneyDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY.
Albert Einstein College of Medicine · USAlma Mater Europaea · SI

Funding

CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
Cognitive intervention to improve simple and complex walkingR01AG050448 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE, VERGHESE, JOE · 2015 to 2019
$4.0M
NCATS NIH HHS UL1 TR002556NIA NIH HHS R01 AG050448
6 · The paper itself

Abstract

objectiveA strong relation between cognition and mobility has been identified in aging, supporting a role for enhancement mobility through cognitive-based interventions. However, a critical evaluation of the consistency of treatment effects of cognitive-based interventions is currently lacking. The objective of this study was 2-fold: (1) to review the existing literature on cognitive-based interventions aimed at improving mobility in older adults and (2) to assess the clinical effectiveness of cognitive interventions on gait performance.

designA systematic review of randomized controlled trials (RCT) of cognitive training interventions for improving simple (normal walking) and complex (dual task walking) gait was conducted in February 2018. SETTING AND

participantsOlder adults without major cognitive, psychiatric, neurologic, and/or sensory impairments were included. MEASURES: Random effect meta-analyses and a subsequent meta-regression were performed to generate overall cognitive intervention effects on single- and dual-task walking conditions.

resultsTen RCTs met inclusion criteria, with a total of 351 participants included in this meta-analysis. Cognitive training interventions revealed a small effect of intervention on complex gait [effect size (ES) = 0.47, 95% confidence interval (CI) 0.13 to 0.81, P = .007, I CONCLUSIONS/IMPLICATIONS: This meta-analysis provides support for the fact that cognitive training interventions can improve mobility-related outcomes, especially during challenging walking conditions requiring higher-order executive functions. Additional evidence from well-designed large-scale randomized clinical trials is warranted to confirm the observed effects.

Indexed as

Cognitive Behavioral TherapyWalkingAgedHumansRandomized Controlled Trials as TopicTask Performance and Analysiscomputerized cognitive trainingelderlyfall riskGait controlneurophysiological plasticity

Identifiers

PMID29680203
PMCPMC6361514
OpenAlexW2799528055

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.