Evidence map›Paper›PMID 29680959›Full record

SynthesisNeuropsychology review2018

Neurocognitive Functioning in Depressed Young People: A Systematic Review and Meta-Analysis.

Joanne Goodall, Caroline Fisher, Sarah Hetrick, Lisa Phillips, Emma M Parrish, Kelly Allott

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neuropsychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 9 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 9 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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  4. Cognitive Functioning in Youth with Anxiety Disorders: A Systematic Review.Clinical child and family psychology review · 2024
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  10. Neural complexity EEG biomarkers of rapid and post-rapid ketamine effects in late-life treatment-resistant depression: a randomized control trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Joanne GoodallOrygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia.
Caroline FisherDepartment of Psychology, Royal Melbourne Hospital, Melbourne Health, Parkville, Australia.
Sarah HetrickCentre for Youth Mental Health, The University of Melbourne, Parkville, Australia.
Lisa PhillipsMelbourne School of Psychological Sciences, The University of Melbourne, Parkville, Australia.
Emma M ParrishDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kelly AllottOrygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, VIC, 3052, Australia. kelly.allott@orygen.org.au.
University of Melbourne · AUHarvard University · USOrygen Youth Health · AUThe Royal Melbourne Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is among the most common mental health problems for young people. In adults, depression is associated with neurocognitive deficits that reduce the effectiveness of treatment and impair educational and vocational functioning. Compared to adults, less is known about the neurocognitive functioning of young people with depression, and existing research has reported inconsistent findings.

methodThis systematic review and meta-analysis synthesized the literature on neurocognitive functioning in currently depressed youth aged 12-25 years in comparison to healthy controls.

resultsFollowing a systematic review of the literature, 23 studies were included in the meta-analysis. Poorer performance in the domains of attention (SMD: .50, 95% CI: .18-.83, p = .002), verbal memory (SMD: .78, 95% CI: .50-1.0, p < .001), visual memory (SMD: .65, 95% CI: .30-.99, p < .001), verbal reasoning/knowledge (SMD: .46; 95% CI: .14-.79; p < 0.001) and IQ (SMD: .32; 95% CI: .08-.56; p = 0.01) were identified in depressed youth. Relative weaknesses in processing speed/reaction time and verbal learning were also evident, however, these findings disappeared when the quality of studies was controlled for. Moderator analysis showed a tendency for poorer set-shifting ability in younger depressed participants relative to controls (although non-significant; p = .05). Moderator analysis of medication status showed taking medication was associated with poorer attentional functioning compared to those not taking medication.

conclusionThe findings suggest that currently depressed young people display a range of neurocognitive weaknesses which may impact treatment engagement and outcome. The findings support the need to consider neurocognitive functioning when treating youth with depression.

Indexed as

CognitionAdolescentAdultChildDepressionHumansYoung AdultAdolescenceDepressionNeurocognitive functionYoung adults

Identifiers

PMID29680959
OpenAlexW2799373761

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.