Evidence map›Paper›PMID 29680985›Full record

SynthesisEuropean journal of nutrition2019

Egg consumption and the risk of cardiovascular disease and all-cause mortality: Guangzhou Biobank Cohort Study and meta-analyses.

Lin Xu, Tai Hing Lam, Chao Qiang Jiang, Wei Sen Zhang, Feng Zhu, Ya Li Jin, Jean Woo, Kar Keung Cheng, G Neil Thomas

Open access · greenAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 12 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 12 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Lin XuSchool of Public Health, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0002-0537-922X
Tai Hing LamSchool of Public Health, The University of Hong Kong, Hong Kong, China. hrmrlth@hku.hk.
Chao Qiang JiangGuangzhou No. 12 Hospital, Guangzhou, 510620, China. cqjiang@hku.hk.
Wei Sen ZhangGuangzhou No. 12 Hospital, Guangzhou, 510620, China.
Feng ZhuGuangzhou No. 12 Hospital, Guangzhou, 510620, China.
Ya Li JinGuangzhou No. 12 Hospital, Guangzhou, 510620, China.
Jean WooDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Kar Keung ChengInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
G Neil ThomasInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.
Twelfth Guangzhou City People's Hospital · CNUniversity of Birmingham · GBChinese University of Hong Kong · HKSun Yat-sen University · CN

Funding

Guangzhou Science and Technology Bureau, Guangzhou, China 2002Z2-E2051Guangzhou Science and Technology Bureau, Guangzhou, China 2012J5100041Guangzhou Science and Technology Bureau, Guangzhou, China 2013J4100031Health and Medical Research Fund 13143241University of Hong Kong Foundation for Educational Development and Research C20400.28505200University of Hong Kong Foundation for Educational Development and Research SN/1f/HKUF-DC
6 · The paper itself

Abstract

purposeEggs are highly nutritious but concerns over their cholesterol content have led to dietary avoidance among many. There are also important international differences in relevant dietary guidance. We conducted the first prospective study in China investigating the association of egg consumption, cardiovascular disease (CVD) mortality, and a meta-analysis.

methodsWe included 28,024 participants without CVD at baseline (2003-8) in Guangzhou Biobank Cohort Study. All-cause and CVD mortality were identified through record linkage. We used Cox proportional hazards regression. We followed the Meta-analysis Of Observational Studies in Epidemiology reporting guidelines.

resultsDuring 275,343 person-years follow-up (average 9.8 years), we found 2685 all-cause and 873 CVD deaths. We found no significant difference in all-cause mortality between higher (7+ eggs/week) and low consumption (< 1 egg/week) [adjusted hazard ratio (HR) 1.08, 95% confidence interval (CI) 0.93-1.24], and mortality from CVD (0.99, 95% CI 0.76-1.27), ischemic heart disease (IHD) (0.92, 95% CI 0.63-1.36), or stroke (0.88, 95% CI 0.57-1.35). The updated meta-analyses including our results showed that 7+ eggs/week was not associated with all-cause mortality (HR 1.09, 95% CI 0.997-1.200) or IHD (HR 0.97, 95% CI 0.90-1.05), but associated with a small reduction in stroke (HR 0.91. 95% CI 0.85-0.98).

conclusionsEating one egg daily is not associated with increase in CVD or all-cause mortality. The small observed reduction in stroke risk needs to be confirmed. Our findings support current guidelines recommending eggs as part of a healthy diet, and should be considered in other dietary recommendations.

Indexed as

Cardiovascular DiseasesChinaCohort StudiesDeathDietEggsFemaleFollow-Up StudiesHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsStrokeSurveys and QuestionnairesCardiovascular diseaseEgg consumptionIschemic heart diseaseMortalityStroke

Identifiers

PMID29680985
OpenAlexW2802393009

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.