Evidence map›Paper›PMID 29686319›Full record

ArticleScientific reports2018

Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study.

Enikő Zsoldos, Nicola Filippini, Abda Mahmood, Clare E Mackay, Archana Singh-Manoux, Mika Kivimäki, Mark Jenkinson, Klaus P Ebmeier

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  10. Racial discrimination associates with lower cingulate cortex thickness in trauma-exposed black women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
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  11. Alzheimer's disease biomarkers in Black and non-Hispanic White cohorts: A contextualized review of the evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Enikő ZsoldosDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. eniko.zsoldos@psych.ox.ac.uk.ORCID 0000-0002-0478-6165
Nicola FilippiniDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Abda MahmoodDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Clare E MackayDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.
Archana Singh-ManouxDepartment of Epidemiology and Public Health, University College London, London, WC1E 7HB, UK.ORCID 0000-0002-1244-5037
Mika KivimäkiDepartment of Epidemiology and Public Health, University College London, London, WC1E 7HB, UK.ORCID 0000-0002-4699-5627
Mark JenkinsonWellcome Centre for Integrative Neuroimaging, Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Klaus P EbmeierDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.ORCID 0000-0002-5190-7038
Warneford Hospital · GBJohn Radcliffe Hospital · GBInserm · FRUniversity College London · GB

Funding

Socio-economic status and heterogeneity in agingR01AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G, SINGH-MANOUX, ARCHANA · 1996 to 2013
$3.5M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
Medical Research Council G1001354Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MR/K013351/1Medical Research Council MR/L023784/1Medical Research Council MR/M024962/1Medical Research Council MR/R024227/1NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG034454Parkinson's UK J-0901
6 · The paper itself

Abstract

The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic load on the ageing brain has been limited. We investigated the relation of mid-life allostatic load index and multifactorial predictors of stroke (Framingham stroke risk) and diabetes (metabolic syndrome) with voxelwise structural grey and white matter brain integrity measures in the ageing Whitehall II cohort (N = 349, mean age = 69.6 (SD 5.2) years, N (male) = 281 (80.5%), mean follow-up before scan = 21.4 (SD 0.82) years). Higher levels of all three markers were significantly associated with lower grey matter density. Only higher Framingham stroke risk was significantly associated with lower white matter integrity (low fractional anisotropy and high mean diffusivity). Our findings provide some empirical support for the concept of allostatic load, linking the effect of everyday stress on the body with features of the ageing human brain.

Indexed as

AgingAllostasisAgedAged, 80 and overCohort StudiesFemaleGray MatterHumansMaleWhite Matter

Identifiers

PMID29686319
PMCPMC5913085
OpenAlexW2801648658

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.