Evidence map›Paper›PMID 29694668›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2018

A Link Between Alzheimer's and Type II Diabetes Mellitus? Ca

Yuko Tsutsui, Franklin A Hays

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Vitamin DOxidative medicine and cellular longevity · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yuko TsutsuiDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Franklin A HaysDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
University of Oklahoma Health Sciences Center · USYale University · US

Funding

Deciphering ShcA-mediated ROS Production as a Novel Intervention Strategy in Diabetes TherapyR01GM118599 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HAYS, FRANKLIN ALAN · 2016 to 2019
$1.1M
NIGMS NIH HHS R01 GM118599
6 · The paper itself

Abstract

We propose protein localization dependent signal activation (PLDSA) as a model to describe pre-existing protein partitioning between the cytosol, and membrane surface, as a means to modulate signal activation, specificity, and robustness. We apply PLDSA to explain possible molecular links between type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) by describing Ca

Indexed as

Alzheimer DiseaseAnimalsCalciumDiabetes Mellitus, Type 2HumansProtein Interaction Domains and MotifsProteinsSignal TransductionCalciumProteinsAlzheimer's diseasebiological signalingprotein-lipid interactionsprotein localizationShcASrctype II diabetes mellitus

Identifiers

PMID29694668
PMCPMC6166406
OpenAlexW2802876390

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.