Evidence map›Paper›PMID 29717377›Full record

SynthesisCurrent hypertension reports2018

A Systematic Review of Sleep, Hypertension, and Cardiovascular Risk in Children and Adolescents.

Aaron D Fobian, Lindsey Elliott, Tinnie Louie

Registry-linked trialOpen access · greenAbstract readSystematic Review
In one paragraph

Synthesis in Current hypertension reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06642246 (Sleep Promotion Among Children Newly Diagnosed With Essential Hypertension), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06642246 narecruitingnot on this mapstarted 2026, after this paper: background citation

Sleep Promotion Among Children Newly Diagnosed With Essential Hypertension

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2026 to 2026Enrolled10ConditionsInsufficient Sleep, HypertensionArmsIntervention
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Guideline
  2. Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
  3. Article
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  6. Article
  7. Review
  8. Review
  9. Article
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  11. Article
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aaron D FobianDepartment of Psychiatry, University of Alabama at Birmingham, 1720 2nd Ave. S., SC 1025, Birmingham, AL, 35294, USA. afobian@uabmc.edu.
Lindsey ElliottDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Tinnie LouieDepartment of Clinical and Diagnostic Science, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

purpose of reviewMany of the risk factors for heart disease have recently been shown to develop during childhood such as left ventricular hypertrophy and fibrous plaque lesions. As risk for cardiovascular disease in children and adolescents has risen, sleep duration has decreased, and inadequate sleep in children and adolescents has been found to be associated with cardiovascular disease risk. The aims of this manuscript are to provide an updated systematic review of the literature assessing sleep, hypertension, and cardiovascular risk and evaluate the strength of the evidence based on the available research. RECENT

findingsA systematic review was conducted using six databases from January 1, 2015 through March 9, 2018. We sought studies which looked at the relationship between sleep duration, sleep timing, or sleep quality and outcome variables of hypertension, inflammation, obesity, glucose or insulin, and lipids in children and adolescents. We found 24 studies which met our criteria. Nine studies included hypertension as an outcome variable; fifteen included obesity; thirteen included glucose or insulin; eight included lipids; and three included measures of inflammation. The existing literature on sleep and cardiovascular disease in children and adolescents is limited and relatively weak. Only one RCT was identified, and the overwhelming majority of studies had a high risk of bias. The strongest evidence of an association with sleep is with obesity, hypertension, and insulin sensitivity. Further research using more standardized methods and objective measures is needed to determine if a causal relationship truly exists between sleep and cardiovascular risk.

Indexed as

AdolescentCardiovascular DiseasesChildHumansHypertensionInsulin ResistanceObesityRisk FactorsSleepSleep Wake DisordersBMICardiovascular diseaseHypertensionInflammationObesitySleep

Identifiers

PMID29717377
PMCPMC8513135
OpenAlexW2802548604

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.