Evidence map›Paper›PMID 29718698›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy.

Corbin A Shields, Maggie McCalmon, Tarek Ibrahim, Dakota L White, Jan M Williams, Babbette LaMarca, Denise C Cornelius

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Immune Cells in Preeclampsia.International journal of molecular sciences · 2025
    Review
  5. Interleukin-1 receptor type 1 inhibition improves blood pressure, fetal growth and immune balance in placental ischemic rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  6. Review
  7. Immunology of Hypertension: Pathophysiological and Therapeutic Aspects.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. VASCULAR AND RENAL MECHANISMS OF PREECLAMPSIA.Current opinion in physiology · 2023
    Article
  15. Article
  16. NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Corbin A ShieldsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, Mississippi.
Maggie McCalmonDepartment of Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Tarek IbrahimDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, Mississippi.
Dakota L WhiteDepartment of Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Jan M WilliamsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, Mississippi.
Babbette LaMarcaDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, Mississippi.
Denise C CorneliusDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center , Jackson, Mississippi.
University of Mississippi Medical Center · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GARRETT, MICHAEL R · 2013 to 2022
$23.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
The Kidney, Hypertension, Pregnancy and InflammationR01HD067541 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI LAMARCA, BABBETTE · 2011 to 2020
$3.1M
Mechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7M
Hypertension and InflammationR00HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2017 to 2019
$747k
Hypertension and InflammationK99HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2016 to 2016
$136k
The role of T lymphocytes in mediating hypertension during pregnancyF32HL108558 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WALLACE, KEDRA L. · 2012 to 2013
$85k
NHLBI NIH HHS F32 HL108558NHLBI NIH HHS K99 HL130456NHLBI NIH HHS R00 HL130456NHLBI NIH HHS T32 HL105324NICHD NIH HHS R01 HD067541NIDDK NIH HHS R01 DK109133NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Previous studies have demonstrated that T-helper 17 (T

Indexed as

Cytotoxicity, ImmunologicLymphocyte ActivationAdoptive TransferAnimalsAntioxidantsCells, CulturedCyclic N-OxidesDisease Models, AnimalFemaleGranzymesInterferon-gammaIschemiaKiller Cells, NaturalOxidative StressPlacentaPore Forming Cytotoxic ProteinsAntioxidantsCyclic N-OxidesGranzymesGzmb protein, ratInterferon-gammaperforin, ratPore Forming Cytotoxic ProteinsSpin Labelstempolhypertensionnatural killer celloxidative stresspregnancyT-helper 17

Identifiers

PMID29718698
PMCPMC6139611
OpenAlexW2799832725

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.