Evidence map›Paper›PMID 29721981›Full record

ArticleAdvances in experimental medicine and biology2018

Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice.

Ammaji Rajala, Yuhong Wang, Raju V S Rajala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ammaji RajalaDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Yuhong WangDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Raju V S RajalaDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. raju-rajala@ouhsc.edu.
University of Oklahoma Health Sciences Center · USDean McGee Eye Institute · US

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2011 to 2025
$9.3M
SECOND MESSENGERS IN THE RETINAR01EY000871 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAJALA, RAJU VS · 1985 to 2020
$7.2M
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY000871
6 · The paper itself

Abstract

Studies form our laboratory and others show that the oncogenic tyrosine kinase and serine threonine kinase signaling pathways are essential for cone photoreceptor survival. These pathways are downregulated in mouse models of retinal degenerative diseases. In the present study, we found that activation mutants of mTOR delayed the death of cones in a mouse model of retinal degeneration. These studies suggest that oncogenic protein kinases may be useful as therapeutic agents to treat retinal degenerations that affect cones.

Indexed as

AnimalsBasic-Leucine Zipper Transcription FactorsCell SurvivalDisease Models, AnimalEye ProteinsGenes, SyntheticInjections, IntraocularMiceMice, Inbred BALB CMice, KnockoutMice, Mutant StrainsPromoter Regions, GeneticReceptor, InsulinRecombinant ProteinsRetinal Cone Photoreceptor CellsRetinitis PigmentosaBasic-Leucine Zipper Transcription FactorsEye ProteinsMTOR protein, humanNrl protein, mouseReceptor, InsulinRecombinant ProteinsTOR Serine-Threonine KinasesCone photoreceptorsInsulin receptormTOROncogeneProtein kinasesRetinal degenerationRetinitis pigmentosaSurvival

Identifiers

PMID29721981
PMCPMC6424566
OpenAlexW2802246762

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.