Evidence map›Paper›PMID 29725596›Full record

ArticleFrontiers in molecular biosciences2018

Substrate Specificity of Cysteine Proteases Beyond the S

Ileana Corvo, Florencia Ferraro, Alicia Merlino, Kathrin Zuberbühler, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Tatiana Basika, Leda Roche, James H McKerrow and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Catalytically Active Recombinant Cysteine Proteases ofInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Coordination chemistry suggests that independently observed benefits of metformin and ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Biguanide is a modifiable pharmacophore for recruitment of endogenous ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ileana CorvoDepartamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Florencia FerraroLaboratorio de Química Teórica y Computacional, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Alicia MerlinoLaboratorio de Química Teórica y Computacional, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.
Kathrin ZuberbühlerDepartment of Pharmaceutical Chemistry, Pharmacology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, United States.
Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA, United States.
Lucía PastroDepartamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Natalia Pi-DenisDepartamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Tatiana BasikaDepartamento de Biología Celular y Molecular, Unidad de Biología Parasitaria, Facultad de Ciencias, Instituto de Higiene, Universidad de la República, Montevideo, Uruguay.
Leda RocheDepartamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
James H McKerrowDepartment of Pathology, Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, San Francisco, CA, United States.
Charles S CraikDepartment of Pharmaceutical Chemistry, Pharmacology, Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, United States.
Conor R CaffreyDepartment of Pathology, Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, San Francisco, CA, United States.
José F TortDepartamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Universidad de la República · UYUniversity of California, San Francisco · USCenter for Discovery · USUniversity of California, San Diego · US

Funding

Allosteric Inhibition of a Family of Proteolytic EnzymesR01GM104659 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM104659
6 · The paper itself

Abstract

Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous

Indexed as

active site conformationcathepsin LFasciola hepaticamolecular dynamics simulationmutagenesisS2 pocket

Identifiers

PMID29725596
PMCPMC5917446
OpenAlexW2802011660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.