Evidence map›Paper›PMID 29728992›Full record

ArticleInternational urology and nephrology2018

Fatigue is associated with high prevalence and severity of physical and emotional symptoms in patients on chronic hemodialysis.

Maurizio Bossola, Enrico Di Stasio, Emanuele Marzetti, Katja De Lorenzis, Gilda Pepe, Carlo Vulpio

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  10. Insights into effective fatigue reducing interventions in kidney transplant candidates: a scoping review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maurizio BossolaHemodialysis Service, Institute of Clinical Surgery, Catholic University of the Sacred Heart, Rome, Italy. maubosso@tin.it.ORCID http://orcid.org/0000-0003-1627-0235
Enrico Di StasioDepartment of Clinical Chemistry, Catholic University of the Sacred Heart, Rome, Italy.
Emanuele MarzettiDepartment of Geriatrics and Gerontology, Catholic University of the Sacred Heart, Rome, Italy.
Katja De LorenzisNurse Team Hemodialysis Service, Catholic University of the Sacred Heart, Rome, Italy.
Gilda PepeDepartment of Emergency Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Carlo VulpioHemodialysis Service, Institute of Clinical Surgery, Catholic University of the Sacred Heart, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe symptom burden of fatigued hemodialysis patients is poorly known. We aimed to investigate possible differences in the prevalence and severity of symptoms between fatigued and not fatigued patients on chronic hemodialysis.

methodsAll prevalent patients on chronic hemodialysis referring to the Hemodialysis Service between January 2016 and June 2017 were considered eligible. The Dialysis Symptom Index (DSI) questionnaire was performed during the dialysis treatment. Patients underwent assessment of fatigue using the Italian version of the vitality scale of the SF-36 (SF-36VS).

resultsWe studied 137 patients: 107 (78.1%) were fatigued and 30 (31.9%) were non-fatigued. The median [95% CI] number of symptoms was 15 [14-16] for patients who reported fatigue and 9 [8-19] for the non-fatigued (P < 0.0001). In fatigued patients, with respect to non-fatigued ones, the prevalence of dry skin, itching, muscle soreness, bone or joint pain, restless legs, shortness of breath, feeling sad, feeling anxious, difficulty concentrating, and difficulty becoming sex aroused was significantly higher. Restless legs, feeling sad, difficulty concentrating, and difficulty becoming sex aroused were symptoms independently associated with fatigue. The severity of dry skin, trouble staying asleep, and bone/joint pain was higher in fatigued patients.

conclusionFatigued hemodialysis patients report suffering from physical and emotional symptoms more frequently than non-fatigued patients. This finding suggests the need to accurately and routinely define the symptom burden of chronic hemodialysis patients and may help to investigate eventually common underlying pathogenic mechanisms of symptoms in these patients.

Indexed as

AdultAge DistributionAnxietyCohort StudiesDepressionFatigueFemaleHospitals, UniversityHumansItalyKidney Failure, ChronicMaleMiddle AgedPrevalencePrognosisRenal DialysisBurdenEnd-stage renal diseaseFatigueHemodialysisPrevalenceSeveritySymptom

Identifiers

PMID29728992

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.