Evidence map›Paper›PMID 29735705›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Taming unruly chloride channel inhibitors with rational design.

Rebecka J Sepela, Jon T Sack

Abstract readComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Chloride Homeostasis Regulates cGAS-STING Signaling.bioRxiv : the preprint server for biology · 2024
    Article
  3. Article
  4. Article
  5. Reduced Expression of TMEM16A Impairs Nitric Oxide-Dependent ClFrontiers in cellular neuroscience · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rebecka J SepelaDepartment of Physiology and Membrane Biology, University of California, Davis, CA 95616.
Jon T SackDepartment of Physiology and Membrane Biology, University of California, Davis, CA 95616 jsack@ucdavis.edu.ORCID 0000-0002-6975-982X

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Visualizing endogenous ion channel activationR01NS096317 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COHEN, BRUCE E, SACK, JON THOMAS · 2016 to 2019
$1.4M
NHLBI NIH HHS R01 HL128537NIGMS NIH HHS T32 GM007377NINDS NIH HHS R01 NS096317
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Chloride ChannelsChloride Channels

Identifiers

PMID29735705
PMCPMC6003517

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.