Evidence map›Paper›PMID 29741807›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2018

Genetically determined pattern of left ventricular function in normal and hypertensive hearts.

Attila Kovács, Andrea Ágnes Molnár, Márton Kolossváry, Bálint Szilveszter, Alexisz Panajotu, Bálint Károly Lakatos, Levente Littvay, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Szilard Voros and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Attila KovácsMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.ORCID 0000-0003-2320-6434
Andrea Ágnes MolnárMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Márton KolossváryMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Bálint SzilveszterMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Alexisz PanajotuMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Bálint Károly LakatosMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Levente LittvayCentral European University, Budapest, Hungary.
Ádám Domonkos TárnokiHungarian Twin Registry, Budapest, Hungary.
Dávid László TárnokiHungarian Twin Registry, Budapest, Hungary.
Szilard VorosGlobal Genomics Group, Atlanta, GA, USA.
György JermendyIII. Department of Internal Medicine, Bajcsy-Zsilinszky Hospital, Budapest, Hungary.
Partho P SenguptaWest Virginia University School of Medicine, Morgantown, WV, USA.
Béla MerkelyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Pál Maurovich-HorvatMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Semmelweis University · HUBajcsy-Zsilinszky Kórház és Rendelőintézet · HUCentral European University · ATID Genomics (United States) · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We sought to assess the inheritance of left ventricular (LV) function using speckle-tracking echocardiography and the impact of hypertension on modifying the genetically determined pattern of contraction in a population of twins. We recruited 92 Caucasian twin pairs, including 74 hypertensive (HTN) siblings. Beyond standard echocardiographic protocol, a speckle-tracking analysis was performed, including global longitudinal strain (GLS). Systolic function, as assessed by ejection fraction, showed moderate heritability (61%); however, GLS showed higher and dominant heritability (75%). Heterogeneity models revealed that there were no differences between the HTN and non-HTN subjects regarding the heritability of GLS. However, the heritability estimates of diastolic function parameters, including early diastolic strain rate, were low. LV systolic biomechanics is highly heritable. GLS shows dominant heritability, despite the presence of early-stage hypertensive heart disease. Early diastolic parameters are rather determined by environmental factors. These findings suggest the presence of a genetic framework that conserves systolic function despite the expression of diastolic dysfunction and may underlie the phenotypic progression towards heart failure with preserved ejection fraction.

Indexed as

Biomechanical PhenomenaDiastoleEchocardiographyEnvironmentFemaleHeart FailureHeart VentriclesHumansHypertensionMaleMiddle AgedObserver VariationPhenotypeProspective StudiesStroke VolumeSystoleechocardiographyglobal longitudinal strainheart failureheart failure with preserved ejection fractionheritabilityHFpEFhypertensive heart diseasespeckle tracking

Identifiers

PMID29741807
PMCPMC8031166
OpenAlexW2801715750

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.