Evidence map›Paper›PMID 29759441›Full record

ReviewAdvances in biological regulation2018

Nuclear organization mediates cancer-compromised genetic and epigenetic control.

Sayyed K Zaidi, Andrew J Fritz, Kirsten M Tracy, Jonathan A Gordon, Coralee E Tye, Joseph Boyd, Andre J Van Wijnen, Jeffrey A Nickerson, Antony N Imbalzano, Jane B Lian and 2 more

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in biological regulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. CENP-A Regulation and Cancer.Frontiers in cell and developmental biology · 2022
    Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sayyed K ZaidiDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Andrew J FritzDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Kirsten M TracyDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Jonathan A GordonDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Coralee E TyeDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Joseph BoydDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Andre J Van WijnenDepartments of Orthopedic Surgery, Biochemistry & Molecular Biology, Mayo Clinic, Rochester, MN, United States.
Jeffrey A NickersonDepartment of Pediatrics, UMass Medical School, Worcester, MA, United States.
Antony N ImbalzanoGraduate Program in Cell Biology and Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, United States.
Jane B LianDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States.
Janet L SteinDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States. Electronic address: janet.stein@uvm.edu.
Gary S SteinDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont, Burlington, VT, United States. Electronic address: gary.stein@uvm.edu.
University of Vermont · USUniversity of Massachusetts Chan Medical School · USMayo Clinic in Arizona · US

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Frances E. Carr · 2017 to 2026
$51.6M
SUBNUCLEAR TARGETING OF TRANSCRIPTION FACTORSP01CA082834 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, GARY S. · 2001 to 2015
$18.4M
NCI NIH HHS P01 CA082834NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

Nuclear organization is functionally linked to genetic and epigenetic regulation of gene expression for biological control and is modified in cancer. Nuclear organization supports cell growth and phenotypic properties of normal and cancer cells by facilitating physiologically responsive interactions of chromosomes, genes and regulatory complexes at dynamic three-dimensional microenvironments. We will review nuclear structure/function relationships that include: 1. Epigenetic bookmarking of genes by phenotypic transcription factors to control fidelity and plasticity of gene expression as cells enter and exit mitosis; 2. Contributions of chromatin remodeling to breast cancer nuclear morphology, metabolism and effectiveness of chemotherapy; 3. Relationships between fidelity of nuclear organization and metastasis of breast cancer to bone; 4. Dynamic modifications of higher-order inter- and intra-chromosomal interactions in breast cancer cells; 5. Coordinate control of cell growth and phenotype by tissue-specific transcription factors; 6. Oncofetal epigenetic control by bivalent histone modifications that are functionally related to sustaining the stem cell phenotype; and 7. Noncoding RNA-mediated regulation in the onset and progression of breast cancer. The discovery of components to nuclear organization that are functionally related to cancer and compromise gene expression have the potential for translation to innovative cancer diagnosis and targeted therapy.

Indexed as

AnimalsBreast NeoplasmsCell NucleusChromatin Assembly and DisassemblyEpigenesis, GeneticHumansMitosis

Identifiers

PMID29759441
PMCPMC6102062
OpenAlexW2802585851

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.