ArticleInternational journal of clinical pharmacy2018
Medication-related problems among adult chronic kidney disease patients in a sub-Saharan tertiary hospital.
Article in International journal of clinical pharmacy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patient reported barriers and facilitators of chronic kidney disease care in Sub-Saharan Africa: a mixed methods systematic review using the COM-B model.BMC nephrology · 2025Pooled it
- Assessment of Appropriate Prescribing in Maintenance Haemodialysis and Comparison of Prescribing Patterns Between State- and Privately-Funded Patients: A Retrospective Review.Hospital pharmacy · 2026Article
- Article
- Development of an evaluation system for rational drug use in patients with chronic kidney disease using the Delphi method.Frontiers in pharmacology · 2024Article
- Drug-related problems and associated factors among patients with kidney dysfunction at a tertiary hospital in southwestern Uganda: a prospective observational study.BMC nephrology · 2023Observational
- Medication Review with Follow-Up for End-Stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated with Medication-A Systematic Review.Journal of clinical medicine · 2023Review
- Impact of a multidisciplinary approach involving clinical pharmacist on resolving drug related problems in chronic kidney patients: a prospective interventional study.BMC nephrology · 2023Article
- Drug-related problems among transfusion-dependent thalassemia patients: A real-world evidence study.Frontiers in pharmacology · 2023Article
- Article
- Risk factors for drug therapy problems among Cambodian Americans with complex needs: a cross-sectional, observational study.Health psychology and behavioral medicine · 2022Article
- Article
- Update on Existing Care Models for Chronic Kidney Disease in Low- and Middle-Income Countries: A Systematic Review.Canadian journal of kidney health and disease · 2022Article
- Management of Drug-Drug Interactions among Critically Ill Patients with Chronic Kidney Disease: Impact of Clinical Pharmacist's Interventions.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Medication non-adherence in chronic kidney disease: a mixed-methods review and synthesis using the theoretical domains framework and the behavioural change wheel.Journal of nephrology · 2021Review
- Sodium-glucose cotransporter 2 inhibitors for diabetic kidney disease: a primer for deprescribing.Clinical kidney journal · 2019Article
- Evaluation of medication adherence and predictors of sub-optimal adherence among pre-dialysis patients with chronic kidney disease.Medicine access @ point of careArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundChronic kidney disease (CKD) patients are prone to medication-related problems (MRPs). Few studies address the clinical relevance of MRPs among CKD patients in sub-Saharan Africa.
objectiveTo investigate the frequency and predictors of MRPs among adult CKD patients treated at a tertiary care facility in an urban sub-Saharan setting.
settingKenyatta National Hospital in Nairobi, Kenya.
methodA cross-sectional study involving 60 adult patients with CKD was carried out. Data were collected through structured interviews and patient chart reviews between April 2016 and June 2016. MRPs identified from the collected data were classified according to Hepler and Strand classification. The frequencies of the identified MRPs were computed and logistic regression used to investigate the associations between the MRPs and covariates in the data.
main outcome measuresfrequencies and predictors of MRPs.
results271 MRPs were identified. The commonest MRPs were drug interactions (21.8%), indication without drug (18.1%) and medication non-adherence (15.5%). Compared to patients with CKD stage 3, patients with CKD stage 4 were 5.9 times more likely to have an improper drug selection and 4.7 times more likely to experience overdosage. Other significant predictors of MRPs were the number of medications per prescription and the number of comorbidities per patient.
conclusionThis study found a high frequency of MRPs among patients with chronic kidney disease receiving care in urban sub-Saharan tertiary hospital settings. The predictors of MRPs among CKD patients in this setting are likely to be multifactorial and include the CKD stage, polypharmacy, and comorbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.