Evidence map›Paper›PMID 29772252›Full record

ArticleFree radical biology & medicine2018

Sulfiredoxin-1 enhances cardiac progenitor cell survival against oxidative stress via the upregulation of the ERK/NRF2 signal pathway.

Xiuchun Li, Pan He, Xiao-Liang Wang, Shuning Zhang, Neil Devejian, Edward Bennett, Chuanxi Cai

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

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  9. Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment.International journal of biological sciences · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. MG53 attenuates nitrogen mustard-induced acute lung injury.Journal of cellular and molecular medicine · 2022
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xiuchun LiCenter for Cardiovascular Sciences, Department of Molecular and Cellular Physiology, & Department of Medicine, Albany Medical College, Albany, NY 12208, USA.
Pan HeCenter for Cardiovascular Sciences, Department of Molecular and Cellular Physiology, & Department of Medicine, Albany Medical College, Albany, NY 12208, USA; Laboratory for Cancer Signal Transduction, Department of Pathology, Xinxiang Medical University, Xinxiang, Henan 453003, PR China.
Xiao-Liang WangCenter for Cardiovascular Sciences, Department of Molecular and Cellular Physiology, & Department of Medicine, Albany Medical College, Albany, NY 12208, USA.
Shuning ZhangCenter for Cardiovascular Sciences, Department of Molecular and Cellular Physiology, & Department of Medicine, Albany Medical College, Albany, NY 12208, USA.
Neil DevejianDivision of Pediatric Cardiothoracic Surgery, Albany Medical Center, NY 12208, USA.
Edward BennettDivision of Cardiothoracic Surgery, Albany Medical Center, NY 12208, USA.
Chuanxi CaiCenter for Cardiovascular Sciences, Department of Molecular and Cellular Physiology, & Department of Medicine, Albany Medical College, Albany, NY 12208, USA. Electronic address: caic@amc.edu.
Albany Medical Center Hospital · USXinxiang Medical University · CN

Funding

Enhancing the effectiveness of human cardiac stem cell therapyR01HL114951 · NHLBI · UNIVERSITY OF LOUISVILLE · PI CAI, CHUANXI · 2012 to 2016
$1.9M
NHLBI NIH HHS R01 HL114951
6 · The paper itself

Abstract

Cardiac stem/progenitor cells (CPCs) have recently emerged as a potentially transformative regenerative medicine to repair the infarcted heart. However, the limited survival of donor cells is one of the major challenges for CPC therapy. Our recent research effort on preconditioning human CPCs (hCPCs) with cobalt protoporphyrin (CoPP) indicated that sulfiredoxin-1 (SRXN1) is upregulated upon preconditioning aldehyde dehydrogenase bright hCPCs (ALDH

Indexed as

Gene Expression RegulationOxidative StressApoptosisCell DifferentiationCells, CulturedCell SurvivalHeartHumansMembrane Potential, MitochondrialMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NF-E2-Related Factor 2Oxidoreductases Acting on Sulfur Group DonorsSignal TransductionStem CellsMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3NFE2L2 protein, humanNF-E2-Related Factor 2Oxidoreductases Acting on Sulfur Group DonorsSRXN1 protein, humanCell survivalERK/NRF2 signaling pathwayHuman ALDH(br) cardiac stem/progenitor cellsOxidative stressSulfiredoxin-1

Identifiers

PMID29772252
PMCPMC5999586
OpenAlexW2804037648

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.