Evidence mapPaperPMID 29789878Full record

Trial reportDiabetologia2018

Nuts as a replacement for carbohydrates in the diabetic diet: a reanalysis of a randomised controlled trial.

David J A Jenkins, Cyril W C Kendall, Benoît Lamarche, Monica S Banach, Korbua Srichaikul, Edward Vidgen, Sandy Mitchell, Tina Parker, Stephanie Nishi, Balachandran Bashyam and 6 more

Erratum issued 2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 7 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00410722 phase2unknown statusnot on this map

Effect of Nuts on Glycemic Control and Cardiovascular Disease Risk in Type 2 Diabetes

TypeinterventionalSponsorUniversity of TorontoRan2006Enrolled90ConditionsType 2 Diabetes, Cardiovascular Disease, Diet TherapyArmsWhole wheat and bran muffin, Mixed tree nuts
NCT04583696 nacompletednot on this map

The Investigation of Effect on Blood Lipid Parameters With Walnut Addition of Diet

TypeinterventionalSponsorEge UniversityRan2014 to 2015Enrolled30ConditionsCardiovascular Risk FactorArmsThe Investigation of effect on Blood Lipid parameters with walnut addition of Diet
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 7 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Review
  11. Believe It or 'Nutrients · 2023
    Review
  12. International journal of molecular sciences · 2023
    Article
  13. Article
  14. The effect of lowering cholesterol through diet on serum prostate-specific antigen levels: A secondary analysis of clinical trials.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Nuts, Cardiovascular Health, and Diabetes.Circulation research · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

David J A JenkinsDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada. david.jenkins@utoronto.ca.
Cyril W C KendallDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Benoît LamarcheSchool of Nutrition, Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada.
Monica S BanachClinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, ON, Canada.
Korbua SrichaikulDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Edward VidgenDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Sandy MitchellClinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, ON, Canada.
Tina ParkerClinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, ON, Canada.
Stephanie NishiDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Balachandran BashyamDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Russell J de SouzaDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Christopher IrelandClinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, ON, Canada.
Sathish C PichikaDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Joseph BeyeneDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
John L SievenpiperDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Robert G JosseDepartment of Nutritional Sciences, Faculty of Medicine, University of Toronto, 5th Floor, Medical Science Building (MSB), 1 Kings College Circle, Toronto, ON, M5S 1A8, Canada.
Canada Research Chairs · CASt. Michael's Hospital · CAMcMaster University · CAUniversité Laval · CAUniversity of Saskatchewan · CAUniversity of Toronto · CA

Funding

CIHR
6 · The paper itself

Abstract

aims/hypothesisIn line with current advice, we assessed the effect of replacing carbohydrate consumption with mixed nut consumption, as a source of unsaturated fat, on cardiovascular risk factors and HbA

methodsA total of 117 men and postmenopausal women with type 2 diabetes who were taking oral glucose-lowering agents and with HbA

resultsA total of 108 participants had post-intervention data available for analysis (full-dose nut group, n = 40; full-dose muffin group, n = 35; half-dose nut group, n = 33). Compared with the full-dose muffin diet, the full-dose nut diet provided 9.2% (95% CI 7.1, 11.3) greater total energy intake from monounsaturated fat. The full-dose nut diet (median intake, 75 g/day) also reduced HbA CONCLUSIONS/

interpretationNut intake as a replacement for carbohydrate consumption improves glycaemic control and lipid risk factors in individuals with type 2 diabetes.

trial registrationClinicalTrials.gov NCT00410722

fundingThe study was funded by the International Tree Nut Council Nutrition Research and Education Foundation, the Peanut Institute, Loblaw Companies and the Canada Research Chairs Program of the Government of Canada.

Indexed as

Dietary CarbohydratesDiet, DiabeticNutsAgedApolipoproteinsBlood Coagulation FactorsBlood GlucoseBlood PressureBody WeightCholesterol, LDLData Interpretation, StatisticalDiabetes Mellitus, Type 2DietFemaleFood AnalysisHumansApolipoproteinsBlood Coagulation FactorsBlood GlucoseCholesterol, LDLDietary CarbohydratesLipidsLipoproteins, LDLBlood lipidsClotting factorsGlycaemic controlNutsType 2 diabetes

Identifiers

PMID29789878
PMCPMC6061153
OpenAlexW2804939250

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.