ArticleBritish journal of pharmacology2018
PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels.
Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Membrane Physiology Symposium April 22nd-23rd, 2024, Napa California, USA.Bioelectricity · 2024Article
- A new polymodal gating model of the proton-activated chloride channel.PLoS biology · 2023Article
- PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels.British journal of pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePharmacological agents that either inhibit or enhance flux of ions through voltage-gated sodium (Na EXPERIMENTAL APPROACH: Electrophysiology and site-directed mutation were used to investigate the effects of PF-06526290 on Na KEY
resultsPF-06526290 greatly slows inactivation of Na CONCLUSIONS AND IMPLICATIONS: These findings suggest that distinct interactions may underlie the two modes of Na
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.