Evidence map›Paper›PMID 29794236›Full record

ArticleAJNR. American journal of neuroradiology2018

Clinical Significance of Intraplaque Hemorrhage in Low- and High-Grade Basilar Artery Stenosis on High-Resolution MRI.

C Zhu, X Tian, A J Degnan, Z Shi, X Zhang, L Chen, Z Teng, D Saloner, J Lu, Q Liu

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  20. Patterns of ischemic posterior circulation strokes: A clinical, anatomical, and radiological review.International journal of stroke : official journal of the International Stroke Society · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 5 countries.

C ZhuFrom the Department of Radiology and Biomedical Imaging (C.Z., D.S.), University of California, San Francisco, San Francisco, California.ORCID 0000-0001-6898-549X
X TianDepartment of Radiology (X.T., Z.S., X.Z., L.C., J.L., Q.L.), Changhai Hospital, Shanghai, China.ORCID 0000-0001-9080-7737
A J DegnanDepartment of Radiology (A.J.D.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-7373-0990
Z ShiDepartment of Radiology (X.T., Z.S., X.Z., L.C., J.L., Q.L.), Changhai Hospital, Shanghai, China.ORCID 0000-0001-7739-7497
X ZhangDepartment of Radiology (X.T., Z.S., X.Z., L.C., J.L., Q.L.), Changhai Hospital, Shanghai, China.ORCID 0000-0003-2703-9565
L ChenDepartment of Radiology (X.T., Z.S., X.Z., L.C., J.L., Q.L.), Changhai Hospital, Shanghai, China.ORCID 0000-0002-3742-9439
Z TengDepartment of Radiology (Z.T.), University of Cambridge, Cambridge, UK.ORCID 0000-0003-3973-6157
D SalonerFrom the Department of Radiology and Biomedical Imaging (C.Z., D.S.), University of California, San Francisco, San Francisco, California.ORCID 0000-0002-6989-8547
J LuDepartment of Radiology (X.T., Z.S., X.Z., L.C., J.L., Q.L.), Changhai Hospital, Shanghai, China.ORCID 0000-0002-0380-7470
Q LiuDepartment of Radiology (X.T., Z.S., X.Z., L.C., J.L., Q.L.), Changhai Hospital, Shanghai, China liuqimd@126.com.ORCID 0000-0002-4105-2160
Second Military Medical University · CNUniversity of California, San Francisco · USChildren's Hospital of Philadelphia · USUniversity of Cambridge · GB

Funding

MRI of Structure and Function in Assessing Hemodynamic Impact on AAA EvolutionR01HL114118 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SALONER, DAVID A · 2014 to 2017
$1.8M
Determinants of Intracranial Aneurysm GrowthR01NS059944 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALONER, DAVID A · 2009 to 2013
$1.7M
Characterization of intracranial vessel wall morphology and inflammation using 3D high resolution MRIK99HL136883 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZHU, CHENGCHENG · 2017 to 2018
$181k
NHLBI NIH HHS K99 HL136883NHLBI NIH HHS R01 HL114118NINDS NIH HHS R01 NS059944
6 · The paper itself

Abstract

background and purposeIntraplaque hemorrhage within intracranial atherosclerotic plaques identified by high-resolution MR imaging has been studied as a potential marker of stroke risk. However, previous studies only examined intracranial arteries with high-grade stenosis (degree of stenosis, >50%). This study aimed to ascertain the clinical relevance of intraplaque hemorrhage in patients with low- and high-grade stenotic basilar artery plaques. MATERIALS AND

methodsPatients with basilar artery stenosis (

resultsIntraplaque hemorrhage was identified in 22 patients (17.5%), including 21 (31.8%) symptomatic patients and 1 (1.7%) asymptomatic patient. Multivariate analysis showed that intraplaque hemorrhage was the strongest independent marker of symptomatic status (odds ratio, 27.5; 95% CI, 3.4-221.5;

conclusionsIntraplaque hemorrhage is present in both low- and high-grade stenotic basilar artery plaques and is independently associated with symptomatic stroke status. Intraplaque hemorrhage may identify high-risk plaque and provide new insight into the management of patient with stroke without significant stenosis.

Indexed as

AgedCarotid StenosisFemaleHemorrhageHumansMagnetic Resonance ImagingMaleMiddle AgedOdds RatioPlaque, AtheroscleroticSensitivity and SpecificityStrokeVertebrobasilar Insufficiency

Identifiers

PMID29794236
PMCPMC6039267
OpenAlexW2803580639

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.