ArticleCurrent topics in behavioral neurosciences
Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? : Adolescent Anhedonia and Posttraumatic Disorders.
Article in Current topics in behavioral neurosciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Adolescents' ventral striatal reward neural activity moderates the association between lifetime trauma exposure and lower depression after 6 months.European journal of psychotraumatology · 2026Article
- Stress-coping behavior during predator odor exposure is associated with differences in decision making.Addiction neuroscience · 2026Article
- Stress-coping behavior during predator odor exposure is associated with differences in decision making.bioRxiv : the preprint server for biology · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- Loneliness and self-concept in the relations between Theory of Mind and social anhedonia in adolescents.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025Article
- Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment.Journal of mood and anxiety disorders · 2024Article
- Infant hedonic/anhedonic processing index (HAPI-Infant): Assessing infant anhedonia and its prospective association with adolescent depressive symptoms.Journal of affective disorders · 2024Article
- Across ages and places: Unpredictability of maternal sensory signals and child internalizing behaviors.Journal of affective disorders · 2024Article
- Contribution of early-life unpredictability to neuropsychiatric symptom patterns in adulthood.Depression and anxiety · 2022Article
- Enduring disruption of reward and stress circuit activities by early-life adversity in male rats.Translational psychiatry · 2022Article
- Children's value-based decision making.Scientific reports · 2022Article
- A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Prospective examination of pre-trauma anhedonia as a risk factor for post-traumatic stress symptoms.European journal of psychotraumatology · 2022Article
- Influence of anhedonic symptom severity on reward circuit connectivity in PTSD.Behavioural brain research · 2021Article
- The Developmental Origins of Opioid Use Disorder and Its Comorbidities.Frontiers in human neuroscience · 2021Review
- Preliminary Evidence for Anhedonia as a Marker of Sexual Trauma in Female Adolescents.Adolescent health, medicine and therapeutics · 2021Article
- Rethinking Concepts and Categories for Understanding the Neurodevelopmental Effects of Childhood Adversity.Perspectives on psychological science : a journal of the Association for Psychological Science · 2021Article
- Negative affective responses to positive events and stimuli in patients with complex dissociative disorders: a mixed-methods pilot study.European journal of psychotraumatology · 2021Article
- Early life stress and development: potential mechanisms for adverse outcomes.Journal of neurodevelopmental disorders · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Anhedonia, the reduced ability to experience pleasure, is a dimensional entity linked to multiple neuropsychiatric disorders, where it is associated with diminished treatment response, reduced global function, and increased suicidality. It has been suggested that anhedonia and the related disruption in reward processing may be critical precursors to development of psychiatric symptoms later in life. Here, we examine cross-species evidence supporting the hypothesis that early life experiences modulate development of reward processing, which if disrupted, result in anhedonia. Importantly, we find that anhedonia may confer risk for later neuropsychiatric disorders, especially posttraumatic stress disorder (PTSD). Whereas childhood trauma has long been associated with increased anhedonia and increased subsequent risk for trauma-related disorders in adulthood, here we focus on an additional novel, emerging direct contributor to anhedonia in rodents and humans: fragmented, chaotic environmental signals ("FRAG") during critical periods of development. In rodents, recent data suggest that adolescent anhedonia may derive from aberrant pleasure/reward circuit maturation. In humans, recent longitudinal studies support that FRAG is associated with increased anhedonia in adolescence. Both human and rodent FRAG exposure also leads to aberrant hippocampal function. Prospective studies are underway to examine if anhedonia is also a marker of PTSD risk. These preliminary cross-species studies provide a critical construct for future examination of the etiology of trauma-related symptoms in adults and for and development of prophylactic and therapeutic interventions. In addition, longitudinal studies of reward circuit development with and without FRAG will be critical to test the mechanistic hypothesis that early life FRAG modifies reward circuitry with subsequent consequences for adolescent-emergent anhedonia and contributes to risk and resilience to trauma and stress in adulthood.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.