Evidence map›Paper›PMID 29802209›Full record

ReviewClinical science (London, England : 1979)2018

Recent advances in the detection of brown adipose tissue in adult humans: a review.

Frank J Ong, Basma A Ahmed, Stephan M Oreskovich, Denis P Blondin, Tahniyah Haq, Norman B Konyer, Michael D Noseworthy, Francois Haman, Andre C Carpentier, Katherine M Morrison and 1 more

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05419726 (Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05419726 recruitingstarted 2023, after this paper: background citation

Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects.

Ran2023Enrolled20Registered outcomes3Posted comparisons0ConditionsObesityArmsSemaglutide Injectable Product (not provided by the study)
Open the trial in the graph
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Brown adipose tissue metabolism in women is dependent on ovarian status.American journal of physiology. Endocrinology and metabolism · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Treatment Resulting Changes in Volumes of High-International journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
  14. Comparison of BMIPP-SPECT/CT toInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021
    Review
  19. Review
  20. [Comparison ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Frank J OngDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Basma A AhmedDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Stephan M OreskovichDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Denis P BlondinDivision of Endocrinology, Department of Medicine, Centre de recherche du CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Tahniyah HaqDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Norman B KonyerImaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada.
Michael D NoseworthyDepartment of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada.
Francois HamanSchool of Human Kinetics, University of Ottawa, 125 University Street, Ottawa, ON, Canada.
Andre C CarpentierImaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada.
Katherine M MorrisonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada gsteinberg@mcmaster.ca kmorrison@mcmaster.ca.
Gregory R SteinbergDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada gsteinberg@mcmaster.ca kmorrison@mcmaster.ca.

Funding

CIHR 144625-1
6 · The paper itself

Abstract

The activation of brown adipose tissue (BAT) is associated with reductions in circulating lipids and glucose in rodents and contributes to energy expenditure in humans indicating the potential therapeutic importance of targetting this tissue for the treatment of a variety of metabolic disorders. In order to evaluate the therapeutic potential of human BAT, a variety of methodologies for assessing the volume and metabolic activity of BAT are utilized. Cold exposure is often utilized to increase BAT activity but inconsistencies in the characteristics of the exposure protocols make it challenging to compare findings. The metabolic activity of BAT in response to cold exposure has most commonly been measured by static positron emission tomography of

Indexed as

Adipose Tissue, BrownHumansHypothermia, InducedMagnetic Resonance ImagingPositron-Emission TomographyPositron Emission Tomography Computed TomographySkin TemperatureSpectroscopy, Near-Infraredbeige adipose tissuebrown adipose tissueinsulin resistanceobesitytype 2 diabetes

Identifiers

PMID29802209

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.