Evidence map›Paper›PMID 29804200›Full record

ArticleGeroScience2018

Accelerated vascular aging and persistent cognitive impairment in older female breast cancer survivors.

Barbara W Carlson, Melissa A Craft, John R Carlson, Wajeeha Razaq, Kelley K Deardeuff, Doris M Benbrook

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  6. Article
  7. Endothelial-to-Mesenchymal Transition: Potential Target of Doxorubicin-Induced Cardiotoxicity.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023
    Review
  8. Article
  9. Review
  10. Cardiovascular ramifications of therapy-induced endothelial cell senescence in cancer survivors.Biochimica et biophysica acta. Molecular basis of disease · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Barbara W CarlsonFran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, 1100 North Stonewall Avenue, Oklahoma City, OK, 73017, USA. Barbara-Carlson@ouhsc.edu.ORCID 0000-0002-4603-4885
Melissa A CraftFran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, 1100 North Stonewall Avenue, Oklahoma City, OK, 73017, USA.
John R CarlsonFran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, 1100 North Stonewall Avenue, Oklahoma City, OK, 73017, USA.
Wajeeha RazaqStephenson Cancer Center, 800 NE 10th Street, Oklahoma City, OK, 73104, USA.
Kelley K DeardeuffFran and Earl Ziegler College of Nursing, University of Oklahoma Health Sciences Center, 1100 North Stonewall Avenue, Oklahoma City, OK, 73017, USA.
Doris M BenbrookDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Oklahoma Health Sciences Center (OUHSC), 975 NE 10th St, BRC 1217A, Oklahoma City, OK, 73104, USA.
University of Oklahoma Health Sciences Center · USOklahoma State University Oklahoma City · US

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
NCI NIH HHS P30 CA225520
6 · The paper itself

Abstract

Advances in breast cancer treatment have markedly increased survivorship over the past three decades, with over 3.1 million survivors expected to live into their 70s and 80s. Without symptom relief interventions, nearly 35% of these survivors will have life-altering and distressing cognitive symptoms. This pilot study explored associations between serum markers of vascular aging, laterality in cerebral oxygenation, and severity of cognitive impairment in women, 12-18 months after chemotherapy for stage 2/3 invasive ductal breast cancer. Fifteen women (52-84 years) underwent a brief cognitive assessment (Montreal Cognitive Assessment [MOCA]) and blood draws to assess markers of vascular aging (interleukin-6 [IL-6], tumor necrosis factor alpha [TNF-α], C-reactive protein [CRP], and insulin growth factor-1 [IGF-1]). All underwent a computer-based test protocol that is known to increase blood flow within the frontal lobes. Percent cerebral oxyhemoglobin saturation (rcSO

Indexed as

AgedAged, 80 and overAgingBreast NeoplasmsCancer SurvivorsCognitive DysfunctionC-Reactive ProteinFemaleHumansInsulin-Like Growth Factor IInterleukin-6Middle AgedOxygen ConsumptionOxyhemoglobinsPilot ProjectsTumor Necrosis Factor-alphaC-Reactive ProteinInsulin-Like Growth Factor IInterleukin-6OxyhemoglobinsTumor Necrosis Factor-alphaCerebral blood flowChemotherapyCognitive symptomsSurvivorshipVascular aging

Identifiers

PMID29804200
PMCPMC6060197
OpenAlexW2804456257

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.