Evidence map›Paper›PMID 29808931›Full record

ArticleThe Journal of physiology2018

Exploring the autoinhibitory domain of the electrogenic Na

Seong-Ki Lee, Walter F Boron

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Inactivation mechanisms of NaCommunications biology · 2025
    Article
  2. Potential Theranostic Roles of SLC4 Molecules in Human Diseases.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Seong-Ki LeeDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.ORCID 0000-0003-1928-4392
Walter F BoronDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.ORCID 0000-0003-4741-7287
University School · US

Funding

PH REGULATION OF EXCITABLE INVERTEBRATE CELLSR01NS018400 · NINDS · YALE UNIVERSITY · PI BORON, WALTER F · 1985 to 2012
$5.1M
NINDS NIH HHS R01 NS018400
6 · The paper itself

Abstract

key pointsSlc4a4 (mouse) encodes at least five variants of the electrogenic sodium/bicarbonate transporter NBCe1. The initial 41 cytosolic amino acids of NBCe1-A and -D are unique; NBCe1-A has high activity. The initial 85 amino acids of NBCe1-B, -C and -E are unique; NBCe1-B and -C have low activity. Previous work showed that deleting residues 1-85 or 40-62 of NBCe1-B, or 1-87 of NBCe1-C, eliminates autoinhibition. These regions also include binding determinants for IRBIT (inositol trisphosphate (IP ABSTRACT: Variant B of the electrogenic Na

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsBicarbonatesCell MembraneChloridesCytoplasmMiceOocytesProtein DomainsSequence HomologySodiumSodium-Bicarbonate SymportersXenopus laevisBicarbonatesChloridesSlc4a4 protein, mouseSodiumSodium-Bicarbonate Symportersacid-base transportersautoinhibitionSLC4A4

Identifiers

PMID29808931
PMCPMC6092277
OpenAlexW2884125182

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.