ArticleJournal of separation science2018
Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements.
Article in Journal of separation science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Phytochemical Profile and In Vivo Assessment of Toxicity and Anti-Inflammatory Activity ofPlants (Basel, Switzerland) · 2026Article
- Enhancing the quality and oxidative stability of sunflower oil during thermal treatment with an ultrasound-extracted pomegranate flower (Frontiers in nutrition · 2026Article
- An Insight on Ellagic Acid Formulations for the Management of Skin Diseases.Molecules (Basel, Switzerland) · 2025Review
- Comprehensive Characterization of Phytochemical Composition, Membrane Permeability, and Antiproliferative Activity ofInternational journal of molecular sciences · 2024Article
- The Effect of Phenolic-Rich Extracts ofNutrients · 2024Article
- Pomegranate flower polysaccharide improves mastitis in mice by regulating intestinal flora and restoring the blood-milk barrier.Frontiers in pharmacology · 2024Article
- Phenolic Profiles, Antioxidant, and Hypoglycemic Activities ofFoods (Basel, Switzerland) · 2023Article
- Comparative analysis of the phenolic contents and antioxidant activities of different parts of two pomegranate (Frontiers in plant science · 2023Article
- Standardized Pomegranate (PomellaMolecules (Basel, Switzerland) · 2022Article
- Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis.Journal of clinical medicine · 2022Article
- Antioxidant and Antimicrobial Activities ofMolecules (Basel, Switzerland) · 2022Article
- Fractionation of Extracts from Black Chokeberry, Cranberry, and Pomegranate to Identify Compounds That Influence Lipid Metabolism.Foods (Basel, Switzerland) · 2022Article
- Article
- Regulation of Plant Tannin Synthesis in Crop Species.Frontiers in genetics · 2022Review
- Antioxidant Activity, α-Glucosidase Inhibition and UHPLC-ESI-MS/MS Profile of Shmar (Plants (Basel, Switzerland) · 2021Article
- Antibacterial Activity ofPlants (Basel, Switzerland) · 2020Article
- Pomegranate (Journal of functional foods · 2019Article
- Primary Metabolites, Anthocyanins, and Hydrolyzable Tannins in the Pomegranate Fruit.Frontiers in plant science · 2019Review
- Levodopa-ReducedNutrients · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pomegranate (Punica granatum L.) fruit and flower extracts, which are rich sources of bioactive phenolics, are widely utilized as ingredients in botanical dietary supplements. While the phenolic characterization of extracts of pomegranate fruit has been previously studied by liquid chromatography with tandem mass spectrometry, there is lack of similar data for pomegranate flowers. Herein, liquid chromatography with time-of-flight tandem mass spectrometry was utilized to comprehensively characterize the phenolics present in two pomegranate extracts, previously studied for their in vitro and in vivo biological effects, namely, a patented commercial pomegranate fruit extract (Pomella®), and a pomegranate flower extract. Seventy-one phenolics were characterized in the pomegranate fruit extract with the vast majority identified in the flower extract. However, only the pomegranate fruit extract contained tannin-glucuronides and two punicalagin isomers (a characteristic pomegranate phenolic) were identified in this extract while four were identified in the flower extract. The previously reported compounds, pomellatannin and punicatannins A/B, were identified as unique chemical markers in the pomegranate fruit and flower extracts, respectively. This study will aid in the quality control, authentication, and standardization of these botanical ingredients to evaluate their potential health benefits in future planned pre-clinical and clinical studies. Also, this is the first phenolic characterization of a pomegranate flower extract using liquid chromatography with tandem mass spectrometry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.