ReviewJournal of immunology research2018
Herbal Compounds Play a Role in Neuroprotection through the Inhibition of Microglial Activation.
Review in Journal of immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Study on Regulatory Mechanism ofMolecules (Basel, Switzerland) · 2026Article
- Review
- Natural drug delivery systems for the treatment of neurodegenerative diseases.Molecular biology reports · 2025Review
- The Anti-Inflammatory Effects and Mechanism of the Submerged Culture ofJournal of fungi (Basel, Switzerland) · 2024Article
- Longevity and anti-aging effects of curcumin supplementation.GeroScience · 2024Review
- Neurobiological effects of gallic acid: current perspectives.Chinese medicine · 2023Review
- The effects of microglia-associated neuroinflammation on Alzheimer's disease.Frontiers in immunology · 2023Review
- Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.Molecules (Basel, Switzerland) · 2022Review
- Chemical Composition and Immunomodulatory Activity of Essential Oils fromMolecules (Basel, Switzerland) · 2021Article
- Natural antioxidants for neuroinflammatory disorders and possible involvement of Nrf2 pathway: A review.Heliyon · 2021Review
- Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy.Frontiers in pharmacology · 2021Article
- Therapeutic Applications of Terpenes on Inflammatory Diseases.Frontiers in pharmacology · 2021Review
- Microglia-targeting nanotherapeutics for neurodegenerative diseases.APL bioengineering · 2020Article
- Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke.Neural regeneration research · 2020Review
- Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases.BioMed research international · 2020Review
- Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis.Molecular neurobiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since microglia possess both neuroprotective and neurotoxic potential, they play a crucial role in the central nervous system (CNS). Excessive microglial activation induces inflammation-mediated neuronal damage and degeneration. At present, numerous herbal compounds are able to suppress neurotoxicity via inhibiting microglial activation. Therefore, many researchers focus on pharmacological inhibitors of microglial activation to ameliorate neurodegenerative disorders. Further work should concentrate on the exploration of new herbal compounds, which characteristically inhibit microglial neurotoxicity, rather than modulating neuroprotection alone. In this review, we summarize these herbal compounds, which in the past several years have been shown to exert potential neuroprotective activity by inhibiting microglial activation. The therapeutic targets and pharmacological mechanisms of these compounds have also been discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.