Evidence map›Paper›PMID 29867549›Full record

ArticleFrontiers in physiology2018

Exercise Training Favorably Modulates Gene and Protein Expression That Regulate Arterial Cholesterol Content in CETP Transgenic Mice.

Paula R Pinto, Karolline S da Silva, Rodrigo T Iborra, Ligia S Okuda, Diego Gomes-Kjerulf, Guilherme S Ferreira, Adriana Machado-Lima, Debora D F M Rocco, Edna R Nakandakare, Ubiratan F Machado and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Physical activity to reduce PCSK9 levels.Frontiers in cardiovascular medicine · 2022
    Review
  5. Novel Biomaterial for Artery Patch in Swine Model With High-Fat Diet.Frontiers in bioengineering and biotechnology · 2021
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Paula R PintoLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Karolline S da SilvaLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Rodrigo T IborraLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Ligia S OkudaLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Diego Gomes-KjerulfLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Guilherme S FerreiraLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Adriana Machado-LimaMestrado em Ciências do Envelhecimento, Universidade São Judas Tadeu, São Paulo, Brazil.
Debora D F M RoccoLaboratório de Fisiologia do Exercício Físico e Saúde da Faculdade de Educação Física e Esportes da Universidade Santa Cecília, São Paulo, Brazil.
Edna R NakandakareLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Ubiratan F MachadoDepartamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de Sao Paulo, São Paulo, Brazil.
Maria L Correa-GiannellaLaboratório de Carboidratos e Radioimunoensaio LIM 18, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sergio CatanoziLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Marisa PassarelliLaboratório de Lípides LIM 10, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aerobic exercise training (AET) improves the reverse cholesterol transport (RCT) in cholesteryl ester transfer protein-transgenic (CETP-tg) mice. We aimed at investigating the role of AET in the expression of genes and proteins involved in lipid flux in the aorta and macrophages of CETP-tg mice. Three-month-old male mice were randomly divided into trained (T; treadmill 15 m/min; 30 min/day) and sedentary (S) groups. After 6 weeks, peritoneal macrophages and the aortic arch were obtained immediately (0 h) or 48 h after the last exercise session. mRNA was determined by RT-qPCR, protein levels by immunoblot and

Indexed as

atherosclerosischolesterol ester transfer proteinexercise trainingmacrophage cholesterol effluxreverse cholesterol transport

Identifiers

PMID29867549
PMCPMC5952009

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.