ArticleThe Journal of experimental medicine2018
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8
Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- AH001: A New Drug Targeting RhoA in Heart Failure.Circulation research · 2026Article
- Inhibiting the Secreted RGDKGE Collagen Peptide Selectively Controls CD8The American journal of pathology · 2026Article
- Review
- RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury.Blood · 2025Article
- Myosin IXB protects immune cells from virus infection.The Journal of general virology · 2025Article
- ARAP1 fine-tunes F-actin polymerization level in lymphocytes through RhoA inhibition.Frontiers in immunology · 2025Article
- Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset.Nature communications · 2023Article
- Article
- Regulator of G-protein signaling 1 critically supports CD8Frontiers in immunology · 2023Article
- The role of angiogenesis in malignant pleural effusion: from basic research to clinical application.American journal of cancer research · 2022Review
- Review
- ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding.EMBO reports · 2021Article
- Journey to the Center of the Cell: Cytoplasmic and Nuclear Actin in Immune Cell Functions.Frontiers in cell and developmental biology · 2021Review
- Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8Frontiers in immunology · 2021Review
- Divergence of Tissue-Memory T Cells: Distribution and Function-Based Classification.Cold Spring Harbor perspectives in biology · 2020Review
- In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Review
- Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures.Nature communications · 2019Article
- Intravital imaging of host-parasite interactions in skin and adipose tissues.Cellular microbiology · 2019Review
- Local Myo9b RhoGAP activity regulates cell motility.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells are actively scanning pMHC-presenting cells in lymphoid organs and nonlymphoid tissues (NLTs) with divergent topologies and confinement. How the T cell actomyosin cytoskeleton facilitates this task in distinct environments is incompletely understood. Here, we show that lack of Myosin IXb (Myo9b), a negative regulator of the small GTPase Rho, led to increased Rho-GTP levels and cell surface stiffness in primary T cells. Nonetheless, intravital imaging revealed robust motility of Myo9b
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.