Evidence mapPaperPMID 29882199Full record

ReviewJournal of nephrology2018

Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice.

Luca De Nicola, Luca Di Lullo, Ernesto Paoletti, Adamasco Cupisti, Stefano Bianchi

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06940414 (Prevalence and Risk Factors of Hyperkalemia in Non-Dialysis Chronic Kidney Disease Patients in a Community-Based Primary Care Setting), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06940414 recruitingnot on this mapstarted 2025, after this paper: background citation

Prevalence and Risk Factors of Hyperkalemia in Non-Dialysis Chronic Kidney Disease Patients in a Community-Based Primary Care Setting

TypeobservationalSponsorXiujuan ZangRan2025 to 2025Enrolled1,890ConditionsHyperkalemia, Chronic Kidney Disease(CKD)ArmsNo Intervention
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Article
  5. Management of hyperkalemia: Expert consensus from Kuwait - a Modified Delphi Approach.International journal of nephrology and renovascular disease · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Medication Optimization for New Initiators of Empagliflozin for Diabetic Kidney Disease.Clinical diabetes : a publication of the American Diabetes Association · 2022
    Article
  13. Article
  14. Article
  15. Observational
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Luca De NicolaDivision of Nephrology, University of Campania, Piazza L. Miraglia, 1, 80138, Naples, Italy. luca.denicola@unicampania.it.
Luca Di LulloNephrology and Dialysis Unit, Parodi-Delfino Hospital, Colleferro, Rome, Italy.
Ernesto PaolettiNephrology, Dialysis and Transplantation, University of Genoa and Policlinico San Martino, Genoa, Italy.
Adamasco CupistiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Stefano BianchiNephrology Unit, Azienda USL Toscana Nord Ovest, Leghorn, Italy.
Azienda Usl Toscana Centro · ITCTO Hospital · ITOspedale Policlinico San Martino · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hyperkalemia is a major complication of chronic kidney disease (CKD) that occurs frequently, heralds poor prognosis, and necessitates careful management by the nephrologist. Current strategies aimed at prevention and treatment of hyperkalemia are still suboptimal, as evidenced by the relatively high prevalence of hyperkalemia in patients under stable nephrology care, and even in the ideal setting of randomized trials where best treatment and monitoring are mandatory. The aim of this review was to identify and discuss a range of unresolved issues related to the management of chronic hyperkalemia in non-dialysis CKD. The following topics of clinical interest were addressed: diagnosis, relationship with main comorbidities of CKD, therapy with inhibitors of the renin-angiotensin-aldosterone system, efficacy of current dietary and pharmacological treatment, and the potential role of the new generation of potassium binders. Opinion-based answers are provided for each of these controversial issues.

Indexed as

Angiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBiomarkersChelating AgentsHumansHyperkalemiaKidneyPotassiumPredictive Value of TestsRenal Insufficiency, ChronicRenin-Angiotensin SystemRisk FactorsTreatment OutcomeAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsBiomarkersChelating AgentsPotassiumAnti-RAASChronic kidney diseaseHyperkalemiaPotassium binder

Identifiers

PMID29882199
PMCPMC6182350
OpenAlexW2807375651

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.