Evidence map›Paper›PMID 29887865›Full record

ArticleFrontiers in immunology2018

Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4

Giada Frascaroli, Carina Lecher, Stefania Varani, Corinna Setz, Johannes van der Merwe, Wolfram Brune, Thomas Mertens

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Frontiers in cellular and infection microbiology · 2020
    Article
  10. Tuning the Orchestra: HCMV vs. Innate Immunity.Frontiers in microbiology · 2020
    Review
  11. The scope of viral causation of human cancers: interpreting virus density from an evolutionary perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  12. HCMV Envelope Glycoprotein Diversity Demystified.Frontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Giada FrascaroliInstitute of Virology, Ulm University Medical Center, Ulm, Germany.
Carina LecherInstitute of Virology, Ulm University Medical Center, Ulm, Germany.
Stefania VaraniDepartment of Diagnostic, Experimental and Specialty Medicine, University of Bologna, Bologna, Italy.
Corinna SetzInstitute of Virology, Ulm University Medical Center, Ulm, Germany.
Johannes van der MerweInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Wolfram BruneHeinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Thomas MertensInstitute of Virology, Ulm University Medical Center, Ulm, Germany.
Leibniz Institute of Virology (LIV) · DEUniversität Ulm · DEUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) persistently infects 40-90% of the human population but in the face of a normal immune system, viral spread and dissemination are efficiently controlled thus preventing clinically signs and disease. HCMV-infected hosts produce a remarkably large amount of HCMV-specific CD4

Indexed as

Antigen PresentationAntigens, ViralCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCytomegalovirusCytomegalovirus InfectionsGene Expression Regulation, ViralHumansImmunologic MemoryLymphocyte ActivationMacrophagesMajor Histocompatibility ComplexViral ProteinsAntigens, ViralViral Proteinshuman cytomegalovirusmacrophagesmajor histocompatibility complex moleculesT-cell activationT-cell proliferationUS2-11 immune evasive genes

Identifiers

PMID29887865
PMCPMC5981096
OpenAlexW2801967705

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.