ArticleFrontiers in cardiovascular medicine2018
Common Methods for Performing Mendelian Randomization.
Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 3 of them syntheses that pooled it.
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Who cites it
91 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Assessing the genetic estimates of the association between plasma caffeine and cancer risk through Mendelian randomization.European journal of nutrition · 2025Pooled it
- Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.Human molecular genetics · 2022Pooled it
- Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.PloS one · 2022Pooled it
- Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank.Nutrients · 2021Trial
- Tau seeds induce neurofibrillary tangle formation across brain regions via individual-specific connectivity.Neuron · 2026Article
- Mendelian-Randomization Study Reveals Causal Relationships Between Blood Metabolites and Psychiatric Disorders.Schizophrenia bulletin · 2026Article
- Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Absence of Association Between Glaucoma and Stroke Risk: Insights From a Cross-Sectional Study and a Two-Sample Mendelian Randomization Study.Journal of ophthalmology · 2026Article
- Cortical structural variations and scoliosis risk: insights from a large-scale Mendelian randomization analysis.Brain & spine · 2026Article
- Identification of potential drug target genes for atopic dermatitis leveraging Mendelian randomization, single-cell transcriptomics, and spatial transcriptomics.Archives of medical science : AMS · 2026Article
- Genetics of Thyroid Function: Relevance for Biology and Disease Management.The Journal of clinical endocrinology and metabolism · 2025Review
- Red Wine May Mitigate the Risk of Intracerebral Hemorrhage by Preventing Hypertension-A Mendelian Randomization Study Combining CHARLS.Food science & nutrition · 2025Article
- Causal associations between cognitive impairments and retinal diseases: A two-sample Mendelian randomization study.The Journal of international medical research · 2025Article
- Plasma proteins and osteosarcoma risk: causal evidence from Mendelian randomization.Discover oncology · 2025Article
- Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study.Discover oncology · 2025Article
- Longitudinal study reveals plasma glycans associations with prediabetes/type 2 diabetes in KORA study.Cardiovascular diabetology · 2025Article
- Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study.Journal of thoracic disease · 2025Article
- Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization.Journal of ovarian research · 2025Article
- Causal associations between Sarcopenia-related traits and obstructive sleep apnea: a mendelian randomization study.Aging clinical and experimental research · 2025Article
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31 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mendelian randomization (MR) is a framework for assessing causal inference using cross-sectional data in combination with genetic information. This paper summarizes statistical methods commonly applied and strait forward to use for conducting MR analyses including those taking advantage of the rich dataset of SNP-trait associations that were revealed in the last decade through large-scale genome-wide association studies. Using these data, powerful MR studies are possible. However, the causal estimate may be biased in case the assumptions of MR are violated. The source and the type of this bias are described while providing a summary of the mathematical formulas that should help estimating the magnitude and direction of the potential bias depending on the specific research setting. Finally, methods for relaxing the assumptions and for conducting sensitivity analyses are discussed. Future researches in the field of MR include the assessment of non-linear causal effects, and automatic detection of invalid instruments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.