Evidence map›Paper›PMID 29894763›Full record

ArticlePharmacological research2019

Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter.

Rebecca L Brindley, Mary Beth Bauer, L Anne Walker, Meagan A Quinlan, Ana M D Carneiro, Ji-Ying Sze, Randy D Blakely, Kevin P M Currie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rebecca L BrindleyDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville TN, USA.
Mary Beth BauerDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville TN, USA.
L Anne WalkerDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville TN, USA.
Meagan A QuinlanDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville TN, USA; Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, USA.
Ana M D CarneiroDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville TN, USA.
Ji-Ying SzeDepartment of Molecular Pharmacology and Rose F. Kennedy Intellectual and Developmental Disabilities Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Randy D BlakelyDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, USA; Florida Atlantic University Brain Institute, Jupiter, FL, USA.
Kevin P M CurrieDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville TN, USA. Electronic address: Currie@rowan.edu.
Vanderbilt University · USCooper Medical School of Rowan University · USAlbert Einstein College of Medicine · USFlorida Atlantic University · US

Funding

Stress-Mediated Alterations in Serotonin 2C Receptor Editing and FunctionP50MH096972 · NIMH · VANDERBILT UNIVERSITY · PI BLAKELY, RANDY D. · 2012 to 2016
$10.5M
Developmental origin of serotonin dysfunction in cortical map disruptionR01MH105839 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SZE, JI Y · 2015 to 2016
$893k
Developmental origin of serotonin dysfunction in cortical map disruptionR56MH105839 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SZE, JI Y · 2018 to 2019
$835k
NIMH NIH HHS P50 MH096972NIMH NIH HHS R01 MH105839NIMH NIH HHS R56 MH105839
6 · The paper itself

Abstract

Adrenal chromaffin cells comprise the neuroendocrine arm of the sympathetic nervous system and secrete catecholamines to coordinate the appropriate stress response. Deletion of the serotonin (5-HT) transporter (SERT) gene in mice (SERT

Indexed as

Adrenal GlandsAnimalsAntidepressive AgentsFemaleMaleMesencephalonMice, TransgenicModels, AnimalRhombencephalonSerotoninSerotonin Plasma Membrane Transport ProteinsSpinal CordTyrosine 3-MonooxygenaseAntidepressive AgentsSerotoninSerotonin Plasma Membrane Transport ProteinsTyrosine 3-MonooxygenaseAdrenal chromaffin cellAdrenal glandCatecholaminesEscitalopram oxalate (CID: 146571)SerotoninSerotonin transporterSympathetic nervous system

Identifiers

PMID29894763
PMCPMC6286867
OpenAlexW2805583349

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.