Evidence map›Paper›PMID 29895030›Full record

ArticleAmerican journal of nephrology2018

National Trends in Emergency Room Visits of Dialysis Patients for Adverse Drug Reactions.

Lili Chan, Aparna Saha, Priti Poojary, Kinsuk Chauhan, Nidhi Naik, Steven Coca, Pranav S Garimella, Girish N Nadkarni

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lili ChanDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Aparna SahaDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Priti PoojaryDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kinsuk ChauhanDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nidhi NaikUniversity of Toronto, Toronto, Ontario, Canada.
Steven CocaDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Pranav S GarimellaDivision of Nephrology-Hypertension, University of California, San Diego, California, USA.
Girish N NadkarniDivision of Nephrology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Icahn School of Medicine at Mount Sinai · USUniversity of California, San Diego · USUniversity of Toronto · CA

Funding

Molecular Basis of Renal DiseasesT32DK007757 · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · 1998 to 2005
$756k
NIDDK NIH HHS K23 DK107908NIDDK NIH HHS K23 DK114556NIDDK NIH HHS T32 DK007757
6 · The paper itself

Abstract

backgroundVarious medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients.

methodsWe utilized a nationally representative database, the Nationwide Emergency Department Sample, from 2008 to 2013, to compare emergency department (ED) visits for dialysis and propensity matched non-dialysis patients. Log binomial regression was used to calculate relative risk of hospital admission and logistic regression to calculate ORs for in-hospital mortality while adjusting for patient and hospital characteristics.

resultsWhile ED visits for ADEs decreased in both groups, they were over 10-fold higher in dialysis patients than non-dialysis patients (65.8-88.5 per 1,000 patients vs. 4.6-5.4 per 1,000 patients respectively, p < 0.001). The top medication category associated with ED visits for ADEs in dialysis patients is agents primarily affecting blood constituents, which has increased. After propensity matching, patient admission was higher in dialysis patients than non-dialysis patients, (88 vs. 76%, p < 0.001). Dialysis was associated with a 3% increase in risk of admission and 3 times the odds of in-hospital mortality (adjusted OR 3, 95% CI 2.7-2.3.3).

conclusionsED visits for ADEs are substantially higher in dialysis patients than non-dialysis patients. In dialysis patients, ADEs associated with agents primarily affecting blood constituents are on the rise. ED visits for ADEs in dialysis patients have higher inpatient admissions and in-hospital mortality. Further studies are needed to identify and implement measures aimed at reducing ADEs in dialysis patients.

Indexed as

Renal DialysisDrug-Related Side Effects and Adverse ReactionsEmergency Service, HospitalFacilities and Services UtilizationFemaleHospitalizationHumansMaleMiddle AgedUnited StatesAdverse drug eventsDialysisEmergency department

Identifiers

PMID29895030
PMCPMC6148753
OpenAlexW2808265942

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.