Evidence map›Paper›PMID 29895199›Full record

ArticleCell cycle (Georgetown, Tex.)2018

The anaphase promoting complex promotes NHEJ repair through stabilizing Ku80 at DNA damage sites.

Chengxian Ma, Kyungsoo Ha, Min-Su Kim, Young-Woock Noh, Han Lin, Lichun Tang, Qing Zhu, Dan Zhang, Huan Chen, Suxia Han and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Chengxian Maa Department of Radiation Oncology , The First Affiliated Hospital of Xi'an Jiaotong University Medical College , Xi'an , China.
Kyungsoo Hab State Key Laboratory of Proteomics , Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of lifeomics , Beijing , China.
Min-Su Kimd New Drug Development Center , Osong Medical Innovation Foundation , Osong , South Korea.
Young-Woock Nohd New Drug Development Center , Osong Medical Innovation Foundation , Osong , South Korea.
Han Linc Department of Molecular Physiology and Biophysics , Baylor College of Medicine , Houston , TX , USA.ORCID 0000-0002-8569-7972
Lichun Tangb State Key Laboratory of Proteomics , Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of lifeomics , Beijing , China.ORCID 0000-0002-1636-9705
Qing Zhue Department of Abdominal Oncology , West China Hospital of Sichuan University , Chengdu , China.
Dan Zhanga Department of Radiation Oncology , The First Affiliated Hospital of Xi'an Jiaotong University Medical College , Xi'an , China.
Huan Chenb State Key Laboratory of Proteomics , Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of lifeomics , Beijing , China.
Suxia Hana Department of Radiation Oncology , The First Affiliated Hospital of Xi'an Jiaotong University Medical College , Xi'an , China.
Pumin Zhangb State Key Laboratory of Proteomics , Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of lifeomics , Beijing , China.
Baylor College of Medicine · USFirst Affiliated Hospital of Xi'an Jiaotong University · CNBeijing Proteome Research Center · CNOsong Medical Innovation Foundation · KRSichuan University · CN

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 1994 to 2015
$21.7M
Spindle Assembly Checkpoint, Chromosome Stability, and CancerR01CA122623 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2008 to 2016
$2.8M
The Function of Cdc14B in DNA Damage Repair and TumorigenesisR01CA116097 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ZHANG, PUMIN · 2006 to 2015
$2.6M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA116097NCI NIH HHS R01 CA122623NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211
6 · The paper itself

Abstract

Double-strand breaks (DSBs) are repaired through two major pathways, homology-directed recombination (HDR) and non-homologous end joining (NHEJ). The choice between these two pathways is largely influenced by cell cycle phases. HDR can occur only in S/G2 when sister chromatid can provide homologous templates, whereas NHEJ can take place in all phases of the cell cycle except mitosis. Central to NHEJ repair is the Ku70/80 heterodimer which forms a ring structure that binds DSB ends and serves as a platform to recruit factors involved in NHEJ. Upon completion of NHEJ repair, DNA double strand-encircling Ku dimers have to be removed. The removal depends on ubiquitylation and proteasomal degradation of Ku80 by the ubiquitin E3 ligases RNF8. Here we report that RNF8 is a substrate of APC

Indexed as

Anaphase-Promoting Complex-CyclosomeAntigens, CDCadherinsCell Cycle CheckpointsDNA-Binding ProteinsDNA Breaks, Double-StrandedDNA DamageDNA End-Joining RepairHEK293 CellsHeLa CellsHumansKu AutoantigenProteolysisUbiquitinationUbiquitin-Protein LigasesAnaphase-Promoting Complex-CyclosomeAntigens, CDCadherinsCDH1 protein, humanDNA-Binding ProteinsKu AutoantigenRNF8 protein, humanUbiquitin-Protein LigasesAnaphase promoting complexCdh1double-strand breaksNHEJ repairRNF8

Identifiers

PMID29895199
PMCPMC6110584
OpenAlexW2808235831

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.