Evidence map›Paper›PMID 29899115›Full record

ArticleThe Journal of biological chemistry2018

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond.

Shee Chee Ong, Alessia Belgi, Bianca van Lierop, Carlie Delaine, Sofianos Andrikopoulos, Christopher A MacRaild, Raymond S Norton, Naomi L Haworth, Andrea J Robinson, Briony E Forbes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shee Chee OngFrom the College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia.
Alessia Belgithe School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
Bianca van Lieropthe School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
Carlie DelaineFrom the College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia.
Sofianos Andrikopoulosthe Department of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia.
Christopher A MacRaildMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Raymond S NortonMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Naomi L Haworththe School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
Andrea J Robinsonthe School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
Briony E ForbesFrom the College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia, briony.forbes@flinders.edu.au.
Monash University · AUFlinders University · AUDeakin University · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of fast-acting and highly stable insulin analogues is challenging. Insulin undergoes structural transitions essential for binding and activation of the insulin receptor (IR), but these conformational changes can also affect insulin stability. Previously, we substituted the insulin A6-A11 cystine with a rigid, non-reducible C=C linkage ("dicarba" linkage). A

Indexed as

AnimalsBlood GlucoseCell LineCrystallography, X-RayCysteineHumansHypoglycemic AgentsInsulinMaleMiceMice, Inbred C57BLMolecular Dynamics SimulationNIH 3T3 CellsProtein ConformationProtein StabilityReceptor, InsulinBlood GlucoseCysteineHypoglycemic AgentsInsulinReceptor, Insulinbiophysical studiesbiophysicsconformational changedicarba peptidesdisulfidedisulfide bondsinsulinmolecular dynamics

Identifiers

PMID29899115
PMCPMC6066309
OpenAlexW2808185730

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.