ArticleNature2018
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.
0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 252 citations in OpenAlex.
- Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid.Annals of neurology · 2020Trial
- A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia.Journal of human genetics · 2018Trial
- Small-Molecule Kinase Inhibitors Modulating Circadian Rhythms.Medicinal research reviews · 2026Review
- Proteomic investigation of signaling dynamics: from static maps to network rewiring.Bioscience reports · 2026Review
- Article
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling.bioRxiv : the preprint server for biology · 2026Article
- A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026Article
- Active zone plasticity couples sleep need to presynaptic hypophosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Targeting hypothalamic SIK3 to promote weight loss and improve glycemic control in mice.Nature communications · 2026Article
- Epigenetic programming by H3K23ac defines lineage fate of Meg3Nature cell biology · 2026Article
- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1.The Journal of cell biology · 2026Article
- State-Dependent Remodeling of Astrocytic Proteome and Phosphorylation Signaling Networks Across Wake, Sleep, and General Anesthesia.International journal of molecular sciences · 2026Article
- Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging.Npj biological timing and sleep · 2026Article
- Absence seizures and sleep-wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder.Epilepsia · 2025Article
- Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Acetylation profiling by Iseq-Kac reveals insights into HSC aging and lineage decision.Nature chemical biology · 2025Article
- Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy.Journal of sleep research · 2025Review
77 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on bySleep it off.2018
Authors and funding
25 authors at 6 institutions in 3 countries.
Zhiqiang WangInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Jing MaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Chika MiyoshiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Yuxin LiDepartments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, TN, USA.
Makito SatoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Yukino OgawaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Tingting LouInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Chengyuan MaNational Institute of Biological Sciences, Beijing, China.
Xue GaoNational Institute of Biological Sciences, Beijing, China.
Chiyu LeeInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Tomoyuki FujiyamaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Xiaojie YangInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Shuang ZhouNational Institute of Biological Sciences, Beijing, China.
Noriko Hotta-HirashimaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Daniela Klewe-NebeniusInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Aya IkkyuInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Miyo KakizakiInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Satomi KannoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Liqin CaoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Satoru TakahashiLaboratory Animal Resource Center, University of Tsukuba, Tsukuba, Japan.
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, St. Jude Proteomics Facility, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yonghao YuDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hiromasa FunatoInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. funato.hiromasa.km@u.tsukuba.ac.jp.
Masashi YanagisawaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. yanagisawa.masa.fu@u.tsukuba.ac.jp.
Qinghua LiuInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan. Qinghua.liu@utsouthwestern.edu.
University of Tsukuba · JPTsukuba International University · JPNational Institute of Biological Sciences, Beijing · CNSt. Jude Children's Research Hospital · USThe University of Texas Southwestern Medical Center · USToho University · JP
Funding
Multi-level Integrative Proteomics to Alzheimer's Disease PathwaysR01AG053987 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2020
$2.2MRNA splicing dysfunction in Alzheimer's diseaseR01AG047928 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2015 to 2019
$1.8MMolecular and Biochemical Basis of mTORC1-mediated Feedback LoopsR01GM114160 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI YU, YONGHAO · 2015 to 2019
$1.6MMolecular Mechanisms of the RNAi/MicroRNA PathwaysR01GM111367 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, QIU-XING, LIU, QINGHUA · 2015 to 2018
$1.4MNIA NIH HHS R01 AG047928NIA NIH HHS R01 AG053987NIGMS NIH HHS R01 GM111367NIGMS NIH HHS R01 GM114160NIH HHS GM111367NIH HHS GM1114160
Abstract
Sleep and wake have global effects on brain physiology, from molecular changes
Indexed as
HomeostasisProteomicsAnimalsBrainGain of Function MutationMaleMemory ConsolidationMiceMice, Inbred C57BLPhosphoproteinsPhosphorylationProtein Serine-Threonine KinasesProteomeSleepSleep DeprivationSynapsesPhosphoproteinsProtein Serine-Threonine KinasesProteomeSIK3 protein, mouse
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.