ArticleSchizophrenia research2018
Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Polygenic risk for schizophrenia is associated with psychomotor vigilance performance impairment during sleep deprivation in women.Translational psychiatry · 2026Article
- Transcriptional signature of induced neurons differentiates virologically suppressed people with HIV from people without HIV.JCI insight · 2026Article
- Effect of polygenic scores on the relationship between psychosis and cognition.Translational psychiatry · 2025Article
- Attention-mediated genetic influences on psychotic symptomatology in adolescence.Nature. Mental health · 2024Article
- Association of polygenic liabilities for schizophrenia and bipolar disorder with educational attainment and cognitive aging.Translational psychiatry · 2024Article
- A Transcriptional Signature of Induced Neurons Differentiates Virologically Suppressed People Living With HIV from People Without HIV.bioRxiv : the preprint server for biology · 2024Article
- Genomic insights into the shared and distinct genetic architecture of cognitive function and schizophrenia.Scientific reports · 2024Article
- Genomic Insights into the Shared and Distinct Genetic Architecture of Cognitive Function and Schizophrenia.medRxiv : the preprint server for health sciences · 2023Article
- Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach.Pharmaceutics · 2022Article
- Article
- Consensus on potential biomarkers developed for use in clinical tests for schizophrenia.General psychiatry · 2022Article
- Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects.The international journal of neuropsychopharmacology · 2021Article
- Associations between hemispheric asymmetry and schizophrenia-related risk genes in people with schizophrenia and people at a genetic high risk of schizophrenia.The British journal of psychiatry : the journal of mental science · 2021Article
- Genetic Risk Assessment in Psychiatry.Cold Spring Harbor perspectives in medicine · 2020Review
- Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls.Translational psychiatry · 2020Article
- Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-Analysis.Journal of clinical medicine · 2020Article
- Genetic Overlap between General Cognitive Function and Schizophrenia: A Review of Cognitive GWASs.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scores showed significant negative correlations with each cognitive domain. Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9). Gene set analysis identified unique and shared genes across cognitive domains. These findings suggest involvement of common and unique mechanisms across cognitive domains and may contribute to the discovery of new therapeutic targets to treat cognitive deficits in schizophrenia.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.