ArticleJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases2018
Depressive Symptoms Are Associated With Low Treatment Adherence in African American Individuals With Systemic Lupus Erythematosus.
Article in Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing and improving communication strategies among healthcare providers and African American individuals with systemic lupus: a scoping review.BMC rheumatology · 2026Pooled it
- The Care-coordination Approach to Learning Lupus Self-Management: a patient navigator intervention for systemic lupus inpatients.Lupus science & medicine · 2021Trial
- Overcoming barriers to recruitment and retention of African-American women with SLE in behavioural interventions: lessons learnt from the WELL study.Lupus science & medicine · 2020Trial
- Barriers, Facilitators, and Preferences for Mental Health Services Among Patients With Systemic Lupus Erythematosus: A Qualitative Study.Arthritis care & research · 2024Article
- Development of the American College of Rheumatology Patient-Reported Outcome Quality Measures for Systemic Lupus Erythematosus.Arthritis care & research · 2024Article
- Article
- Factors Associated With the Initiation and Retention of Patients With Lupus in the Chronic Disease Self-Management Program.Arthritis care & research · 2023Article
- Moderators and Mediators of the Relationship of Shared Decision-Making and Satisfaction.Journal of patient experience · 2023Article
- Persistence of Depression and Anxiety despite Short-Term Disease Activity Improvement in Patients with Systemic Lupus Erythematosus: A Single-Centre, Prospective Study.Journal of clinical medicine · 2022Article
- How Can We Enhance Adherence to Medications in Patients with Systemic Lupus Erythematosus? Results from a Qualitative Study.Journal of clinical medicine · 2022Article
- Medication adherence in systemic lupus erythematosus during Brazilian COVID-19 pandemic.Lupus · 2022Article
- Patient Perception of Depressive Symptoms in Rheumatic Diseases: A Cross-sectional Survey.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2022Article
- Depression-, Pain-, and Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus.International journal of rheumatology · 2022Article
- The Effect of Travel Burden on Depression and Anxiety in African American Women Living with Systemic Lupus.Healthcare (Basel, Switzerland) · 2021Article
- Lupus Cohorts.Rheumatic diseases clinics of North America · 2021Review
- Pathways linking census tract typologies with subjective neighborhood disorder and depressive symptoms in the Black Women's Experiences Living with Lupus (BeWELL) Study.Health & place · 2021Article
- Racial Disparities in Medication Adherence between African American and Caucasian Patients With Systemic Lupus Erythematosus and Their Associated Factors.ACR open rheumatology · 2020Article
- Exploring the Perceived Impact of the Chronic Disease Self-Management Program on Self-Management Behaviors among African American Women with Lupus: A Qualitative Study.ACR open rheumatology · 2020Article
- Update on lupus epidemiology: advancing health disparities research through the study of minority populations.Current opinion in rheumatology · 2019Review
- Chronic Cutaneous Lupus Erythematosus: Depression Burden and Associated Factors.American journal of clinical dermatology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveAfrican American (AA) people with systemic lupus erythematosus (SLE) are at high morbidity and mortality risk, and they often require multiple medications. Low medication adherence is a highly prevalent, multidimensional problem associated with poor outcomes in people with SLE. Depression, a predictor of low adherence in people with chronic conditions, has been described in over 35% of AAs with SLE. We hypothesized that depressive symptoms would be increasingly associated with low adherence in this population.
methodsResearch subjects predominantly belong to the Georgians Organized Against Lupus cohort, a population-based cohort of predominantly AA individuals with SLE in the Atlanta metropolitan area. Medication adherence and severity of depressive symptoms were measured using validated self-reported tools: the 8-item Morisky Medication Adherence Scale and the 9-item Patient Health Questionnaire, respectively. We used univariate and multivariate logistic regression to examine the odds ratios of low medication adherence across individuals with increasing severity of depressive symptoms.
resultsAmong 632 AA SLE participants, 336 (54%) reported low medication adherence and 217 (34.6%) reported "moderate" or "severe" depressive symptoms. In univariate logistic regression, significant risk factors for low adherence were depressive symptoms, low self-efficacy, poor satisfaction with care, female sex, younger age, hurried patient-physician communication, poorer shared decision-making, less compassionate physician communication style, poor/fair health, and higher disease activity score. In multivariate regression, younger age, female sex, and more severe depressive symptoms were associated with low medication adherence.
conclusionsThis is the first study to examine factors associated with low medication adherence among a population-based cohort of AA individuals with SLE. Depression was a strong correlate of low medication adherence. Mental health interventions aiming to address and treat depression may increase medication adherence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.