ReviewVeterinary immunology and immunopathology2018
Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species.
Review in Veterinary immunology and immunopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Characterization and mechanistic regulation of the Bovine inflammasome.Veterinary research communications · 2026Article
- A Comprehensive Review of the Bovine Immune Response to Pathogens.International journal of molecular sciences · 2025Review
- Molecular Changes in the Brain of the WinteringInternational journal of molecular sciences · 2023Article
- Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents.Frontiers in immunology · 2023Review
- Role of Pyroptosis in Intervertebral Disc Degeneration and Its Therapeutic Implications.Biomolecules · 2022Review
- A comprehensive guide to studying inflammasome activation and cell death.Nature protocols · 2020Article
- Innate Immune Response to Tick-Borne Pathogens: Cellular and Molecular Mechanisms Induced in the Hosts.International journal of molecular sciences · 2020Review
- Characterization of equine inflammasomes and their regulation.Veterinary research communications · 2020Article
- Characterization of the NLRP1 inflammasome response in bovine species.Innate immunity · 2020Article
- Inflammatory Responses of Porcine MoDC and Intestinal Epithelial Cells in a Direct-Contact Co-culture System Following a Bacterial Challenge.Inflammation · 2020Article
- Comparison between linseed expeller and canola expeller on concentrate intake, and circulating inflammatory mediators in Holstein calves.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2020Article
- Dynamic Interplay of Host and Pathogens in an Avian Whole-Blood Model.Frontiers in immunology · 2020Article
- Defying Death - HowThe Yale journal of biology and medicine · 2019Review
- LPS-induced NLRP3 gene expression in chicken.Open veterinary journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The inflammasome serves as a mechanism by which the body senses damage or danger. These multiprotein complexes form in the cytosol of myeloid, epithelial and potentially other cell types to drive caspase-1 cleavage and the secretion of the pro-inflammatory cytokines IL-1β and IL-18. Different types of inflammasomes, centered on (and named after) their cytosolic NLRs, respond to signals from bacteria, fungi, and viruses, as well as "sterile inflammatory" triggers. Despite the large body of research accumulated on rodent and human inflammasomes over the past 15 years, only recently have studies expanded to consider the role of inflammasomes in veterinary and wildlife species. Due to the key role of inflammasomes in mediating inflammatory responses observed in humans and rodents, characterization of the similarities and differences between humans/rodents and veterinary species is required to identify genetic and evolutionary influences on disease responses and to develop therapeutic candidates for use in veterinary inflammatory syndromes. Here, we summarize recent findings on inflammasomes in swine, cattle, dogs, bats, small ruminants, and birds. We describe current gaps in our knowledge and highlight promising areas for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.