Trial reportMenopause (New York, N.Y.)2018
Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report.
Trial report in Menopause (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05293860 (Effects of Connective Tissue Manipulation on Menopausal Symptoms), which is not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Connective Tissue Manipulation on Menopausal Symptoms
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Effects of jazz dance and concurrent training on psychological variables in menopausal women: A randomized controlled trial.Archives of women's mental health · 2025Trial
- Characterizing the Autonomic Correlates of Negative Emotion Differentiation: Bridging Laboratory and Daily Life Assessments.Psychophysiology · 2025Article
- A Novel Theoretical Hypothesis on Comorbidity in the Elderly-The Disease of Sympathetic Overdrive (DSO).Aging medicine (Milton (N.S.W)) · 2025Article
- Observational
- Improving Cardiovascular Clinical Competencies for the Menopausal Transition: A Focus on Cardiometabolic Health in Midlife.JACC. Advances · 2025Article
- Unveiling gender differences in psychophysiological dynamics: support for a two-dimensional autonomic space approach.Frontiers in human neuroscience · 2024Article
- Examining the Role of GLU/GABA to GLN Metabolic Cycle in the Pathogenesis of Post-Stroke Depressive Disorder and Insomnia.Neuropsychiatric disease and treatment · 2023Article
- Exploration of a Brain-Liver-Communication-Related Mechanism Involved in the Experimental Perimenopausal Depression Rat Model using Chaihu-Shugan-San.Neurochemical research · 2022Article
- Analysis of Early Warning Diagnostic Indexes and Influencing Factors of Anxiety and Depression in Patients with Arrhythmia.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Effects of aerobics training on anxiety, depression and sleep quality in perimenopausal women.Frontiers in psychiatry · 2022Article
- Anxiety and hemodynamic reactivity during cardiac stress testing: The role of gender and age in myocardial ischemia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Ventromedial Prefrontal Cortex Activity and Sympathetic Allostasis During Value-Based Ambivalence.Frontiers in behavioral neuroscience · 2021Article
- Cross system autonomic balance and regulation: Associations with depression and anxiety symptoms.Psychophysiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of the study was to examine whether anxiety and depressive symptoms are associated with an adverse cardiac autonomic profile among midlife women with hot flashes.
methodsAnxiety and depressive symptoms were evaluated by validated self-administered questionnaires among peri- and postmenopausal women in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, and respiratory sinus arrhythmia (RSA), a marker of parasympathetic activation, were measured at baseline and 12 weeks using impedance cardiography and electocardiography. Multivariable repeated measures linear regression models examined associations between anxiety and depression symptoms and autonomic markers, corrected for multiple comparisons with Benjamini-Hochberg procedure, and adjusted for age and body mass index.
resultsAmong the 121 participants, greater state anxiety was associated with shorter PEP, reflecting higher sympathetic activity (β = -0.24, P = 0.02). Greater trait anxiety and cognitive anxiety were associated with lower RSA, reflecting decreased parasympathetic activity (β = -0.03, P < 0.01 for Spielberger Trait Anxiety; β = -0.06, P = 0.02 for Hospital Anxiety and Depression Scale [HADS] Anxiety Subscale). Greater depressive symptoms were associated with lower RSA (β = -0.06, P = 0.03 for HADS Depression Subscale; β = -0.03, P = 0.04 for Beck Depression Inventory).
conclusionsAmong peri- and postmenopausal women with hot flashes, greater self-reported anxiety and depressive symptoms were associated with lower levels of resting cardiac parasympathetic activity, and greater state anxiety was associated with higher levels of cardiac sympathetic activity. Findings suggest that midlife women with increased anxiety and depressive symptoms may have an unfavorable cardiac autonomic profile with potential implications for their overall cardiovascular risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.