Evidence map›Paper›PMID 29922333›Full record

ReviewDental research journal

Association of vitamin D receptor BsmI, TaqI, FokI, and ApaI polymorphisms with susceptibility of chronic periodontitis: A systematic review and meta-analysis based on 38 case -control studies.

Fatemeh Mashhadiabbas, Hossein Neamatzadeh, Rezvan Nasiri, Elnaz Foroughi, Soudabeh Farahnak, Parisa Piroozmand, Mahta Mazaheri, Masoud Zare-Shehneh

Open access · goldAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Dental research journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  4. ASSOCIATION OF RS2435357 AND RS1800858 POLYMORPHISMS IN RET PROTO-ONCOGENE WITH HIRSCHSPRUNG DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019
    Pooled it
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  7. Ethical Considerations and Equipoise in Cancer Surgery.Indian journal of surgical oncology · 2024
    Review
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  14. Association ofIranian journal of public health · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Fatemeh MashhadiabbasDepartment of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Rezvan NasiriDepartments of Restorative and Esthetic, Arak University of Medical Science, Arak, Iran.
Elnaz ForoughiPediatric Dentistry, Arak University of Medical Science, Arak, Iran.
Soudabeh FarahnakEndodontics, Dental School, Arak University of Medical Science, Arak, Iran.
Parisa PiroozmandDepartment of Oral and Maxillofacial Medicine, Dental School, Ardabil University of Medical Science, Ardabil, Iran.
Mahta MazaheriDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Masoud Zare-ShehnehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Arak University · IRShahid Sadoughi University of Medical Sciences and Health Services · IRArdabil University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere has been increasing interest in the study of the association between Vitamin D receptor (VDR) gene polymorphisms and risk of chronic periodontitis. However, the results remain inconclusive. To better understand the roles of VDR polymorphisms (BsmI, TaqI, FokI, and ApaI) in chronic periodontitis susceptibility, we conducted this systematic review and meta-analysis. MATERIALS AND

methodsThe PubMed, Google Scholar, and Web of Science database were systemically searched to determine all the eligible studies about VDR polymorphisms and risk of chronic periodontitis up to April 2017. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between VDR polymorphisms and chronic periodontitis risk. All the statistical analyses were performed by Comprehensive Meta-Analysis. All

resultsFinally, a total of 38 case-control studies in 19 publications were identified which met our inclusion criteria. There are ten studies with 866 chronic periodontitis cases and 786 controls for BsmI, 16 studies with 1570 chronic periodontitis cases and 1676 controls for TaqI, five studies with 374 chronic periodontitis cases and 382 controls for FokI, and seven studies with 632 chronic periodontitis cases and 604 controls for ApaI. Overall, no significant association was observed between VDR gene BsmI, TaqI, FokI, and ApaI polymorphisms and risk of chronic periodontitis in any genetic model. Subgroup analysis stratified by ethnicity suggested a significant association between BsmI polymorphism and chronic periodontitis risk in the Caucasian subgroup under allele model (A vs. G: OR = 1.747, 95% CI = 1.099-2.778,

conclusionOur results suggest that BsmI, TaqI, FokI, and ApaI polymorphisms in the VDR gene might not be associated with risk of chronic periodontitis in overall population.

Indexed as

Chronic periodontitismeta-analysispolymorphismVitamin D receptor

Identifiers

PMID29922333
PMCPMC5958531
OpenAlexW2802184098

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.