Evidence map›Paper›PMID 29923643›Full record

ArticleMolecular microbiology2018

Functional plasticity of antibacterial EndoU toxins.

Karolina Michalska, Dinh Quan Nhan, Julia L E Willett, Lucy M Stols, William H Eschenfeldt, Allison M Jones, Josephine Y Nguyen, Sanna Koskiniemi, David A Low, Celia W Goulding and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system-exported toxins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
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  7. Sequential rescue and repair of stalled and damaged ribosome by bacterial PrfH and RtcB.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Cryptic Genes for Interbacterial Antagonism DistinguishFrontiers in cellular and infection microbiology · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.Protein science : a publication of the Protein Society · 2020
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Karolina MichalskaMidwest Center for Structural Genomics, Argonne National Laboratory, Argonne, IL, USA.
Dinh Quan NhanDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
Julia L E WillettDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
Lucy M StolsMidwest Center for Structural Genomics, Argonne National Laboratory, Argonne, IL, USA.
William H EschenfeldtMidwest Center for Structural Genomics, Argonne National Laboratory, Argonne, IL, USA.
Allison M JonesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
Josephine Y NguyenDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
Sanna KoskiniemiDepartment of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
David A LowDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
Celia W GouldingDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA, USA.
Andrzej JoachimiakMidwest Center for Structural Genomics, Argonne National Laboratory, Argonne, IL, USA.
Christopher S HayesDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA.
University of California, Santa Barbara · USArgonne National Laboratory · USIrvine University · USUppsala University · SE

Funding

Midwest Center for Structural GenomicsU54GM094585 · NIGMS · UNIVERSITY OF CHICAGO · PI MINOR, WLADEK · 2010 to 2014
$33.7M
The Midwest Center for Structural Genomics - Community ResourceR24GM115586 · NIGMS · UNIVERSITY OF CHICAGO · PI JOACHIMIAK, ANDRZEJ · 2015 to 2017
$2.8M
Structure-function analysis of polymorphic CDI toxin-immunity protein complexes aU01GM102318 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOULDING, CELIA · 2012 to 2016
$1.7M
Molecular mechanisms of antibacterial CDI toxin activationR01GM117373 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GOULDING, CELIA, HAYES, CHRISTOPHER S. · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM117373NIGMS NIH HHS R24 GM115586NIGMS NIH HHS U01 GM102318NIGMS NIH HHS U54 GM094585
6 · The paper itself

Abstract

Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein. The contact-dependent growth inhibition toxin CdiA-CT

Indexed as

Amino Acid SequenceAnti-Bacterial AgentsBacterial ToxinsEndoribonucleasesEscherichia coliEscherichia coli ProteinsRNA, TransferSequence Analysis, ProteinAnti-Bacterial AgentsBacterial ToxinsEndoribonucleasesEscherichia coli ProteinsRNA, Transfer

Identifiers

PMID29923643
PMCPMC6173971
OpenAlexW2809661014

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.