SynthesisBMC endocrine disorders2018
Postoperative tight glycemic control significantly reduces postoperative infection rates in patients undergoing surgery: a meta-analysis.
Synthesis in BMC endocrine disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Risk factors of nosocomial infection after percutaneous coronary intervention: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Impact of diabetes on patients undergoing total ankle arthroplasty: a meta-analysis and systematic review.Endocrine journal · 2025Pooled it
- Hepatic clamping and postoperative hyperglycaemia: A retrospective cohort study in liver surgery.European journal of anaesthesiology and intensive care · 2026Article
- How does blood sugar level affect wound infection rates and device revision and removal rates after hypoglossal nerve stimulation in obstructive sleep apnea patients? A large database study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Assessment of the causal effect of lifestyle factors on postoperative infections based on Mendelian randomization.Medicine · 2025Article
- Optimising cardiac surgery outcomes in people with diabetes: the OCTOPuS pilot feasibility study.Health technology assessment (Winchester, England) · 2025Article
- The diabetic paradox differs in patients with prediabetes and normal glucose regulation after colorectal surgery.BMC surgery · 2025Article
- Combined pathogenic characteristics to analyze susceptibility factors of postoperative pneumonia in patients undergoing cardiac surgery.Journal of cardiothoracic surgery · 2025Article
- Association Between Daily Insulin Dose Adjustments and Glycemic Control in Noncritically Ill Hospitalized Hyperglycemic Patients: A Retrospective Cohort Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025Article
- Application and research progress of the rapid rehabilitation concept in the perioperative gynaecological period.Frontiers in oncology · 2025Review
- Assessing the predictive value of time-in-range level for the risk of postoperative infection in patients with type 2 diabetes: a cohort study.Frontiers in endocrinology · 2025Article
- Randomized Controlled Trial: Does the Use of Occlusive Hydrocolloid Silver-Containing Wound Dressing after Sternotomy Reduce Surgical Site Infection after Cardiac Surgery?Life (Basel, Switzerland) · 2024Article
- Perioperative Antibiotic Prophylaxis—Indications and Modalities for the Prevention of Postoperative Wound Infection.Deutsches Arzteblatt international · 2024Review
- Surgical and oncologic outcomes in surgically treated women 80 years and older with endometrioid endometrial cancer as a function of their comorbidities.Gynecologic oncology reports · 2023Article
- Article
- Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update.Infection control and hospital epidemiology · 2023Article
- Characterization of perioperative glycemic status and dexamethasone use with associated postoperative complications in glioblastoma patients.Acta neurochirurgica · 2023Article
- Article
- A Pharmacist-Led Practice to Improve Perioperative Glycemic Control in Elective Surgery.Clinical diabetes : a publication of the American Diabetes Association · 2023Article
- Reference Ranges of Glycemic Variability in Infants after Surgery-A Prospective Cohort Study.Nutrients · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe benefit results of postoperative tight glycemic control (TGC) were controversial and there was a lack of well-powered studies that support current guideline recommendations.
methodsThe EMBASE, MEDLINE, and the Cochrane Library databases were searched utilizing the key words "Blood Glucose", "insulin" and "Postoperative Period" to retrieve all randomized controlled trials evaluating the benefits of postoperative TGC as compared to conventional glycemic control (CGC) in patients undergoing surgery.
resultsFifteen studies involving 5053 patients were identified. As compared to CGC group, there were lower risks of total postoperative infection (9.4% vs. 15.8%; RR 0.586, 95% CI 0.504 to 0.680, p < 0.001) and wound infection (4.6% vs. 7.2%; RR 0.620, 95% CI 0.422 to 0.910, p = 0.015) in TGC group. TGC also showed a lower risk of postoperative short-term mortality (3.8% vs. 5.4%; RR 0.692, 95% CI 0.527 to 0.909, p = 0.008), but sensitivity analyses showed that the result was mainly influenced by one study. The patients in the TGC group experienced a significant higher rate of postoperative hypoglycemia (22.3% vs. 11.0%; RR 3.145, 95% CI 1.928 to 5.131, p < 0.001) and severe hypoglycemia (2.8% vs. 0.7%; RR 3.821, 95% CI 1.796 to 8.127, p < 0.001) as compared to CGC group. TGC showed less length of ICU stay (SMD, - 0.428 days; 95% CI, - 0.833 to - 0.022 days; p = 0.039). However, TGC showed a neutral effect on neurological dysfunction (1.1% vs. 2.4%; RR 0.499, 95% CI 0.219 to 1.137, p = 0.098), acute renal failure (3.3% vs. 5.4%, RR 0.610, 95% CI 0.359 to 1.038, p = 0.068), duration of mechanical ventilation (p = 0.201) and length of hospitalization (p = 0.082).
conclusionsTGC immediately after surgery significantly reduces total postoperative infection rates and short-term mortality. However, it might limit conclusion regarding the efficacy of TGC for short-term mortality in sensitivity analyses. The patients in the TGC group experienced a significant higher rate of postoperative hypoglycemia. This study may suggest that TGC should be administrated under close glucose monitoring in patients undergoing surgery, especially in those with high postoperative infection risk.
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