Evidence mapPaperPMID 29930739Full record

ArticleTheranostics2018

Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge.

Jia-Jian Wang, Chang Liu, Kun Shan, Bai-Hui Liu, Xiu-Miao Li, Shu-Jie Zhang, Rong-Mei Zhou, Rui Dong, Biao Yan, Xing-Huai Sun

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 74 citations in OpenAlex.

  1. Emerging role of circular RNAs in diabetic retinopathy.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Emerging roles of circular RNAs in retinal diseases.Neural regeneration research · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Circular RNAs in cardiovascular diseases.Pharmacology & therapeutics · 2022
    Review
  14. Article
  15. Emerging Roles ofFrontiers in genetics · 2022
    Review
  16. Article
  17. circ-ZNF609: A potent circRNA in human cancers.Journal of cellular and molecular medicine · 2021
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jia-Jian WangEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Chang LiuThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Kun ShanEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Bai-Hui LiuDepartment of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.
Xiu-Miao LiThe Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Shu-Jie ZhangEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Rong-Mei ZhouEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Rui DongDepartment of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.
Biao YanEye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Xing-Huai SunNHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.
Eye & ENT Hospital of Fudan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Chinese Academy of Sciences · CNFudan University · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is a major cause of visual impairment characterized by progressive retinal neurodegeneration. Circular RNAs are a class of endogenous noncoding RNAs that regulate gene expression in eukaryotes. In this study, we investigated the role of cZNF609 in retinal neurodegeneration induced by glaucoma.

Indexed as

AnimalsCell ProliferationEpendymoglial CellsFluorescent Antibody TechniqueGene Expression ProfilingGlaucomaGliosisIntercellular Signaling Peptides and ProteinsMicroRNAsNerve Tissue ProteinsNeurodegenerative DiseasesNeurogliaRats, Sprague-DawleyReal-Time Polymerase Chain ReactionRetinaRNA, CircularIntercellular Signaling Peptides and ProteinsMETRN protein, humanMicroRNAsMIRN615 microRNA, ratNerve Tissue ProteinsRNA, CircularTrans-ActivatorsZfp609 protein, ratcircular RNAglaucomamicroRNA spongeretinal neurodegeneration

Identifiers

PMID29930739
PMCPMC6010990
OpenAlexW2805199236

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.