Evidence map›Paper›PMID 29934525›Full record

ArticleNature communications2018

Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions.

Tomoyuki Murakami, Jiwon Kim, Yi Li, Glenn Edward Green, Ariella Shikanov, Akira Ono

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Modeling Immunity In Vitro: Slices, Chips, and Engineered Tissues.Annual review of biomedical engineering · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. PIPScience advances · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Endothelial Cells Promote Productive HIV Infection of Resting CD4AIDS research and human retroviruses · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Lymph Node Stromal Cells: Mapmakers of T Cell Immunity.International journal of molecular sciences · 2020
    Review
  15. Review
  16. Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tomoyuki MurakamiDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-6645-2240
Jiwon KimDepartment of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Yi LiDepartment of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-2984-0436
Glenn Edward GreenDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ariella ShikanovDepartment of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-0159-6419
Akira OnoDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. akiraono@umich.edu.ORCID http://orcid.org/0000-0001-7841-851X
University of Michigan · US

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Mechanisms that determine subcellular sites of HIV-1 assemblyR37AI071727 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Akira Ono · 2017 to 2026
$6.2M
Mechanisms that determine subcellular sites of HIV-1 assemblyR01AI071727 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ONO, AKIRA · 2007 to 2016
$3.6M
Effects of lymphoid tissue stromal cells on cell-to-cell HIV-1 spreadR21AI120815 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ONO, AKIRA · 2015 to 2016
$411k
NIAID NIH HHS R01 AI071727NIAID NIH HHS R21 AI120815NIAID NIH HHS R37 AI071727NIDCR NIH HHS T32 DE007057University of Michigan (U-M) MCubedU.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI071727U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21 AI120815U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) T32 DE007057
6 · The paper itself

Abstract

Fibroblastic reticular cells (FRCs) are stromal cells in secondary lymphoid organs, the major sites for HIV-1 infection of CD4

Indexed as

Blood Buffy CoatDendritic CellsFibroblastsHeLa CellsHIV-1HumansHyaluronan ReceptorsHyaluronic AcidLymphatic SystemPalatine TonsilProtein BindingStromal CellsTissue Culture TechniquesT-LymphocytesVirus ReplicationCD44 protein, humanHyaluronan ReceptorsHyaluronic Acid

Identifiers

PMID29934525
PMCPMC6015004
OpenAlexW2809189428

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.