Evidence map›Paper›PMID 29937214›Full record

ArticleMolecular metabolism2018

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr

Anita Patel, Bernardo Yusta, Dianne Matthews, Maureen J Charron, Randy J Seeley, Daniel J Drucker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Diet-dependent sex differences in the response to vertical sleeve gastrectomy.American journal of physiology. Endocrinology and metabolism · 2021
    Article
  11. Article
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  13. Review
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  18. Review
  19. Metabolic Effects of Bile Acids: Potential Role in Bariatric Surgery.Cellular and molecular gastroenterology and hepatology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anita PatelNeuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Surgery, Internal Medicine and Nutritional Science, University of Michigan, Ann Arbor, MI, USA.
Bernardo YustaDepartment of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, M5G 1X5, Canada.
Dianne MatthewsDepartment of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, M5G 1X5, Canada.
Maureen J CharronDepartment of Biochemistry, Medicine (Endocrinology), Albert Einstein College of Medicine, USA; Department of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, USA.
Randy J SeeleyDepartment of Surgery, Internal Medicine and Nutritional Science, University of Michigan, Ann Arbor, MI, USA.
Daniel J DruckerDepartment of Medicine, Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Ontario, M5G 1X5, Canada. Electronic address: drucker@lunenfeld.ca.
University of Toronto · CAUniversity of Michigan · USAlbert Einstein College of Medicine · US

Funding

Pilot and Feasibility ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$4.9M
Pilot and Feasibility (P and F) ProgramP30DK089503 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$1.2M
CIHRNIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS U24 DK097153
6 · The paper itself

Abstract

objectiveTherapeutic interventions that improve glucose homeostasis such as attenuation of glucagon receptor (Gcgr) signaling and bariatric surgery share common metabolic features conserved in mice and humans. These include increased circulating levels of bile acids (BA) and the proglucagon-derived peptides (PGDPs), GLP-1 and GLP-2. Whether BA acting through TGR5 (Gpbar1) increases PGDP levels in these scenarios has not been examined. Furthermore, although the importance of GLP-1 action has been interrogated in Gcgr

methodsTo assess whether BA acting through Gpbar1 mediates improved glucose homeostasis in Gcgr

resultsCirculating levels of BA were markedly elevated yet similar in Gcgr

conclusionsThese findings reveal that GLP-2R controls BA levels and relative proportions of BA species in Gcgr

Indexed as

AnimalsBile Acids and SaltsBlood GlucoseBody WeightDiet, High-FatGastrectomyGlucagonGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide 2Glucagon-Like Peptide-2 ReceptorGlucoseGlucose Tolerance TestHomeostasisInsulinMaleBile Acids and SaltsBlood GlucoseGlucagonGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide 2Glucagon-Like Peptide-2 ReceptorGlucoseGpbar1 protein, mouseInsulinProglucagonReceptors, GlucagonReceptors, G-Protein-CoupledBariatric surgeryBile acidsDiabetesGLP-1GLP-2GlucagonGlucoseObesity

Identifiers

PMID29937214
PMCPMC6157461
OpenAlexW2805241084

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.