Evidence map›Paper›PMID 29939820›Full record

ArticleHuman vaccines & immunotherapeutics2018

Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.

Xintao Hu, Zhongyan Lu, Antonio Valentin, Margherita Rosati, Kate E Broderick, Niranjan Y Sardesai, Preston A Marx, James I Mullins, George N Pavlakis, Barbara K Felber

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. EfficientFrontiers in immunology · 2023
    Article
  6. HIV T-cell immunogen design and delivery.Current opinion in HIV and AIDS · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xintao Hua Human Retrovirus Pathogenesis Section, Center for Cancer Research, National Cancer Institute at Frederick , Frederick , MD , USA.ORCID 0000-0002-6552-9357
Zhongyan Lua Human Retrovirus Pathogenesis Section, Center for Cancer Research, National Cancer Institute at Frederick , Frederick , MD , USA.ORCID 0000-0001-9898-0710
Antonio Valentinb Human Retrovirus Section, Vaccine Branch, Center for Cancer Research , National Cancer Institute at Frederick , Frederick, Frederick , MD , USA.
Margherita Rosatib Human Retrovirus Section, Vaccine Branch, Center for Cancer Research , National Cancer Institute at Frederick , Frederick, Frederick , MD , USA.ORCID 0000-0003-3173-9716
Kate E Broderickc Inovio Pharmaceuticals, Inc. , Plymouth Meeting , PA , USA.ORCID 0000-0003-2682-2363
Niranjan Y Sardesaic Inovio Pharmaceuticals, Inc. , Plymouth Meeting , PA , USA.ORCID 0000-0001-6920-1167
Preston A Marxd Tulane National Primate Research Center and Department of Tropical Medicine, School of Public Health and Tropical Medicine , Tulane University , New Orleans , LA , USA.ORCID 0000-0002-6955-2511
James I Mullinse Departments of Microbiology, Medicine and Laboratory Medicine , University of Washington , Seattle , WA , USA.ORCID 0000-0002-4461-8158
George N Pavlakisb Human Retrovirus Section, Vaccine Branch, Center for Cancer Research , National Cancer Institute at Frederick , Frederick, Frederick , MD , USA.ORCID 0000-0002-4027-4036
Barbara K Felbera Human Retrovirus Pathogenesis Section, Center for Cancer Research, National Cancer Institute at Frederick , Frederick , MD , USA.ORCID 0000-0001-8925-8128
Frederick National Laboratory for Cancer Research · USInovio Pharmaceuticals (United States) · USTulane University · USUniversity of Washington · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Immunotherapeutic Approaches for AIDSZIABC010749 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PAVLAKIS, GEORGE N. · 2009 to 2022
$21.6M
Viral Determinants of HIV-1 Transmission in African HeterosexualsP01AI057005 · NIAID · UNIVERSITY OF WASHINGTON · PI MULLINS, JAMES IVAN · 2003 to 2014
$20.5M
Posttranscriptional control of gene expressionZIABC010334 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FELBER, BARBARA K · 2009 to 2025
$15.1M
NIAID NIH HHS P01 AI057005NIAID NIH HHS P30 AI027757NIH HHS P51 OD011104
6 · The paper itself

Abstract

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27

Indexed as

AIDS VaccinesAnimalsConserved SequenceEpitopes, T-LymphocyteGene Products, envGene Products, gagImmunization ScheduleMacacaMaleSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeT-Lymphocytes, CytotoxicVaccines, DNAViremiaAIDS VaccinesEpitopes, T-LymphocyteGene Products, envGene Products, gagSAIDS VaccinesVaccines, DNAConserved sequencesDNAHIVimmunizationinfectionSIVvaccine

Identifiers

PMID29939820
PMCPMC6183272
OpenAlexW2811086536

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.