GLP-1 receptor agonists × cardiovascular events

TrialDiabetes & vascular disease research2018

Cardiovascular outcomes in patients who experienced a myocardial infarction while treated with liraglutide versus placebo in the LEADER trial.

Michael A Nauck et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 864 people · 2018

Range includes no effect

No clear effect on cardiovascular events

−9%−34% to +26%

Bigger than 1 in 10 for cardiovascular events

As reported

HR 0.91, 95% CI 0.66–1.26

One number in the abstract

the abstract, start to end

placebo ( n = 85, 26.7%; hazard ratio: 0.91; 95% confidence interval: 0.66,

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.910.66–1.26
GLP-1 receptor agonistsCardiovascular events

GLP-1 receptor agonists × cardiovascular eventshelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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12 papers cite it

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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 29947247