SynthesisRheumatology international2018
Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.
Synthesis in Rheumatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07746466 (Efficacy of Bioactive Collagen Peptide Versus Glucosamine and Chondroitin Sulphate in Grade I-III Knee Osteoarthritis), which is not on this map. Cited by 54 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Bioactive Collagen Peptide Versus Glucosamine and Chondroitin Sulphate in Grade I-III Knee Osteoarthritis: A Randomized Controlled Trial
Who cites it
54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Glucosamine for knee osteoarthritis: an umbrella review.Frontiers in nutrition · 2026Pooled it
- Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.Aging clinical and experimental research · 2025Pooled it
- Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials-SYSADOAs Are Effective and Safe for Knee OA.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.BioMed research international · 2020Pooled it
- Extraction and characterization of biomaterials from pork bones: a potential alternative of pineapple by-product extract for commercial proteases.Food science of animal resources · 2026Article
- Effects of D-Glucosamine on the Growth of Human Gut-Dominant MicrobiotaJournal of applied glycoscience · 2026Article
- Diet in Knee Osteoarthritis-Myths and Facts.Nutrients · 2025Review
- Glucosamine Inhibits the Proliferation of Hepatocellular Carcinoma Cells by Eliciting Apoptosis, Autophagy, and the Anti-Warburg Effect.Scientifica · 2025Article
- Article
- Biomechanical and biological features of hyaluronic acid in combination with chondroitin and platelet rich plasma for regenerative medicine applications.Frontiers in bioengineering and biotechnology · 2025Article
- Comparative Efficacy of Glucosamine-Based Combination Therapies in Alleviating Knee Osteoarthritis Pain: A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2024Review
- Is microfracture sufficient for high-tibial osteotomy, or should intra-articular hyaluronic acid and oral glucosamine-chondroitin be used as additional treatments?Journal of orthopaedic surgery and research · 2024Article
- Comparison of functional performance outcomes between oral patented crystalline glucosamine sulfate and platelet-rich plasma among knee osteoarthritis patients: a propensity score matching analysis.Aging clinical and experimental research · 2024Article
- The effect of combined hydrolyzed type 2 collagen, methylsulfonylmethane, glucosamine sulfate and chondroitin sulfate supplementation on knee osteoarthritis symptoms.Turkish journal of physical medicine and rehabilitation · 2024Article
- Article
- Wharton's jelly and osteoarthritis of the knee.British medical bulletin · 2024Review
- Evaluation of the Cartinorm Use in the Therapy of Patients with Knee Osteoarthritis.Materia socio-medica · 2024Article
- Serum Metabolomic Alteration in Rats with Osteoarthritis Treated with Palm Tocotrienol-Rich Fraction Alone or in Combination with Glucosamine Sulphate.Life (Basel, Switzerland) · 2023Article
- Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although glucosamine and chondroitin sulfate have showed beneficial effects on joint tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable. Hence, a systematic review and meta-analysis of randomized placebo-controlled trials was conducted to investigate the efficacy of glucosamine and chondroitin sulfate on knee OA symptoms. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered glucosamine and/or chondroitin sulfate on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and/or the Visual Analog Scale (VAS). Meta-analysis was conducted using a random-effects model and generic inverse-variance method. Heterogeneity was tested using the I
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.