Evidence mapPaperPMID 29952553Full record

ArticleACS chemical biology2018

Parathyroid Hormone Senses Extracellular Calcium To Modulate Endocrine Signaling upon Binding to the Family B GPCR Parathyroid Hormone 1 Receptor.

Kelly J Culhane, Morgan E Belina, Jeremiah N Sims, Yingying Cai, Yuting Liu, Pam S P Wang, Elsa C Y Yan

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Potential mechanisms linking psychological stress to bone health.International journal of medical sciences · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kelly J CulhaneDepartment of Molecular Biophysics and Biochemistry , Yale University , 266 Whitney Avenue , New Haven , Connecticut 06520 , United States.ORCID 0000-0001-8075-4782
Morgan E Belina
Jeremiah N Sims
Yingying Cai
Yuting Liu
Pam S P Wang
Elsa C Y YanDepartment of Chemistry , Yale University , 225 Prospect Street , New Haven , Connecticut 06520 , United States.ORCID 0000-0002-3583-1627
Whitney Museum of American Art · USYale University · US

Funding

PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
NIGMS NIH HHS T32 GM008283
6 · The paper itself

Abstract

Parathyroid hormone (PTH) binds to a family B G protein coupled receptor, parathyroid hormone 1 receptor (PTH1R). One of its functions is to regulate Ca

Indexed as

Signal TransductionAmino Acid SequenceCalciumCyclic AMPHEK293 CellsHumansModels, MolecularParathyroid HormoneProtein BindingReceptor, Parathyroid Hormone, Type 1CalciumCyclic AMPParathyroid HormonePTH1R protein, humanReceptor, Parathyroid Hormone, Type 1

Identifiers

PMID29952553
PMCPMC10640708
OpenAlexW2810665803

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.